TMEM47: A Potential Drug Target and Biomarker for Brain Cell Membrane Protein 1

Target Name: TMEM47

NCBI ID: G83604

TMEM47

TMEM47: A Potential Drug Target and Biomarker for Brain Cell Membrane Protein 1

Brain cell membrane protein 1 (TMEM47) is a transmembrane protein that plays a crucial role in the structure and function of brain cells. It is expressed in various brain regions and functions in cell-to-cell and cell-to-matrix interactions, as well as in the regulation of the blood-brain barrier (BBB). The identification and characterization of TMEM47 as a potential drug target and biomarker for various neurological and psychiatric disorders has significant implications for the development of new therapeutic approaches.

Purpose of the Review

The brain is a complex and dynamic system that relies on the tight regulation of various proteins to maintain proper cell function and ensure the preservation of brain health. One of these proteins, TMEM47, has been shown to be involved in various physiological processes in the brain, including cell-to-cell and cell-to-matrix interactions, as well as the regulation of the BBB. The potential drug targeting of TMEM47 and its potential as a biomarker for various neurological and psychiatric disorders make it an attractive target for further investigation.

History of TMEM47

TMEM47, also known as brain cell membrane protein 1, was first identified in the 1990s as a member of the transmembrane protein family 1 (TMPF) in the brain. It is characterized by a transmembrane domain and various cytoplasmic domains, including an N-terminal cytoplasmic domain, a pre-尾 chain, and a C-terminal transmembrane domain. TMEM47 is primarily expressed in the brain and other nervous tissue, and its localization to the cell surface is confirmed by various techniques, such as co-immunoprecipitation and biotinylated proteins.

Function of TMEM47

TMEM47 is involved in various physiological processes in the brain, including:

1. Cell-to-cell and cell-to-matrix interactions: TMEM47 is known to be involved in the regulation of cell-to-cell interactions, as well as cell-to-matrix interactions. It has been shown to interact with various intracellular signaling pathways, including the TGF-β pathway, which plays a crucial role in the development and maintenance of brain cells.
2. BBB regulation: TMEM47 is also involved in the regulation of the BBB, which is a specialized barrier that separates the brain from the bloodstream. The BBB is designed to allow certain molecules to pass through while keeping others out, ensuring the delivery of essential nutrients and medications to the brain while preventing unauthorized access by harmful molecules. TMEM47 has been shown to regulate the expression of genes involved in the BBB, including the tight junction protein (TJP) and the anion gap channel (AGC).
3. Cell survival and apoptosis: TMEM47 has been shown to play a role in the regulation of cell survival and apoptosis. It has been shown to interact with various signaling pathways, including the Bcl-2 pathway, which is involved in the regulation of cell apoptosis.

Drug Targeting of TMEM47

The potential drug targeting of TMEM47 is based on its involvement in various physiological processes in the brain. Several studies have shown that TMEM47 can be targeted by small molecules, including inhibitors of its signaling pathways, such as the TGF-β pathway.

One of the most promising TMEM47 drug targets is the inhibitor, TMB-2, which is a small molecule that inhibits the activity of the TGF-β pathway. TMB-2 has been shown to protect against neurotoxicity in various cellular and animal models, including the HCA rat model, suggesting that it may be an effective drug against neurodegenerative diseases.

Another potential drug target for TMEM47 is the inhibitor, NBD-2 (N-acetyl-尾-D-maltoside), which is a natural compound that inhibits the activity of the

Protein Name: Transmembrane Protein 47

Functions: Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B. During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity)

The "TMEM47 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM47 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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