TMEM64: A Potential Drug Target and Biomarker (G169200)

Target Name: TMEM64

NCBI ID: G169200

TMEM64

TMEM64: A Potential Drug Target and Biomarker

TMEM64 is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the transmembrane protein family and is involved in the regulation of various cellular processes, including cell signaling, ion transport, and protein synthesis. TMEM64 has also been shown to play a role in the development and progression of certain diseases, including neurodegenerative disorders and cardiovascular disease. As a result, TMEM64 has potential as a drug target and biomarker.

TMEM64 functions as a transmembrane protein that is involved in the regulation of various cellular processes. It is a member of the transmembrane protein family, which means that it is produced in the cell's membrane and functions as a protein that spans the membrane. TMEM64 is involved in the regulation of ion transport, which is the movement of charged particles, such as ions, across the membrane. It is also involved in the regulation of protein synthesis, which is the process by which cells produce the proteins that they need to function.

One of the most interesting functions of TMEM64 is its role in the development and progression of certain diseases. For example, TMEM64 has been shown to be involved in the development of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells and the development of characteristic symptoms, such as difficulty with memory, balance, and movement.

In addition to its potential role in the development of neurodegenerative disorders, TMEM64 has also been shown to be involved in the development and progression of certain cardiovascular conditions, such as heart failure and hypertension. These conditions are characterized by the progressive loss of heart muscle and the development of complications, such as shortness of breath, dizziness, and lightheadedness.

As a result of its involvement in the regulation of cellular processes and its potential role in the development and progression of certain diseases, TMEM64 has potential as a drug target. By targeting TMEM64 with drugs, researchers hope to be able to treat or prevent the development of these conditions. Additionally, TMEM64 may also be used as a biomarker to diagnose and monitor the progress of these conditions.

In conclusion, TMEM64 is a protein that is involved in the regulation of various cellular processes and has been shown to play a role in the development and progression of certain diseases. As a result, TMEM64 has potential as a drug target and biomarker. Further research is needed to fully understand the role of TMEM64 in these processes and to develop effective treatments for the prevention and treatment of these conditions.

Protein Name: Transmembrane Protein 64

Functions: Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1

The "TMEM64 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM64 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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