TMEM67: A Potential Drug Target for Tissue Repair and Regeneration

Target Name: TMEM67

NCBI ID: G91147

TMEM67

TMEM67: A Potential Drug Target for Tissue Repair and Regeneration

TMEM67 (Tissue Membrane Extravagant Marker-67) is a protein that is expressed in various tissues throughout the body, including the skin, lungs, heart, and kidneys. It is a member of the superfamily of transmembrane proteins, which are a type of protein that spans the membrane of a cell and is involved in various cellular processes.

TMEM67 is of particular interest as a potential drug target due to its unique structure and expression patterns. The protein has a length of approximately 67 amino acids and is expressed in various tissues throughout the body. It is highly expressed in the skin, where it is found in the dermis, epidermis, and sweat glands. It is also expressed in the lungs, where it is found in the alveolar macrophages and the blood vessels. Finally, it is expressed in the kidneys, where it is found in the glomeruli and the interstitial cells.

TMEM67 is a protein that is involved in various cellular processes that are important for tissue repair and regeneration. It is a member of the transforming growth factor beta (TGF-β) signaling pathway, which is a well-known pathway that is involved in the regulation of cellular growth, differentiation, and survival. TGF-β signaling is a critical pathway that is involved in the development and maintenance of tissues, and it is thought to be involved in the regulation of TMEM67 expression.

One of the key functions of TMEM67 is its role in cell signaling. It is involved in the regulation of cell proliferation, differentiation, and survival, and it is thought to play a key role in the regulation of cell cycle progression. TMEM67 is a positive regulator of the cyclin D1 (CDK4) gene, which is involved in the regulation of cell cycle progression. It is also a negative regulator of the p21 (CDK6) gene, which is involved in the regulation of cell growth and stability.

TMEM67 is also involved in the regulation of cellular adhesion. It is a member of the cadherin family of transmembrane proteins, which are involved in the regulation of cell-cell adhesion. TMEM67 is thought to play a key role in the regulation of cadherin function, and it is involved in the regulation of cell-cell adhesion in various tissues.

In addition to its role in cell signaling and adhesion, TMEM67 is also involved in the regulation of inflammation. It is a member of the intercellular adhesion molecule (ICAM) family, which is involved in the regulation of cell-cell adhesion and inflammation. TMEM67 is thought to play a key role in the regulation of ICAM function, and it is involved in the regulation of inflammatory responses.

TMEM67 is also involved in the regulation of stem cell proliferation and maintenance. It is a member of the stem cell factor (SCF) family of proteins, which are involved in the regulation of stem cell proliferation and maintenance. TMEM67 is thought to play a key role in the regulation of SCF function, and it is involved in the regulation of stem cell proliferation and differentiation.

In conclusion, TMEM67 is a protein that is expressed in various tissues throughout the body and is involved in various cellular processes that are important for tissue repair and regeneration. It is a member of the TGF-β signaling pathway and is involved in the regulation of cell proliferation, differentiation, and survival. TMEM67 is also involved in the regulation of cell signaling, adhesion, inflammation, and stem cell proliferation and maintenance. As a potential drug target, TMEM67 is a promising target for the development of new therapies for various diseases.

Protein Name: Transmembrane Protein 67

Functions: Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Is a key regulator of stereociliary bundle orientation (By similarity). Required for epithelial cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC). Involved in the negative regulation of canonical Wnt signaling, and activation of the non-canonical cascade stimulated by WNT5A (PubMed:26035863). In non-canonical Wnt signaling, it may act as ROR2 coreceptor (By similarity)

The "TMEM67 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM67 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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