TMEM35A: A Potential Drug Target for Cell Adhesion, Signaling and Survival

Target Name: TMEM35A

NCBI ID: G59353

TMEM35A

TMEM35A: A Potential Drug Target for Cell Adhesion, Signaling and Survival

TMEM35A, also known as NACHO, is a protein that is expressed in various tissues throughout the body. It is a member of the transmembrane protein family and is characterized by the presence of a transmembrane region and a cytoplasmic tail. TMEM35A has been identified as a potential drug target and has been shown to play a role in a variety of biological processes.

TMEM35A is involved in the regulation of cell adhesion, which is the process by which cells stick together to form tissues and organs. It is part of the cadherin family of transmembrane proteins, which includes cadherins and hercins. These proteins help to maintain the integrity of cell membranes and play a role in cell-cell adhesion.

TMEM35A is also involved in the regulation of cell signaling, particularly in the context of the Wnt signaling pathway. Wnt is a signaling pathway that is important for the development and maintenance of tissues and organs, and it is activated in response to the presence of certain proteins, including Wnt. TMEM35A has been shown to be a critical component of the Wnt signaling pathway and has been shown to play a role in the regulation of cell signaling.

In addition to its role in cell adhesion and signaling, TMEM35A is also involved in the regulation of cell survival. It has been shown to play a role in the regulation of cell apoptosis, which is the process by which cells die and are removed from the body. This is important for the maintenance of tissue homeostasis and is critical for the development and maintenance of tissues and organs.

TMEM35A is also involved in the regulation of cell migration, which is the process by which cells move from one location to another in the body. It is part of the cadherin family of transmembrane proteins and has been shown to play a role in the regulation of cell migration. This is important for the development and maintenance of tissues and organs and is critical for the development and maintenance of tissues and organs.

TMEM35A is also involved in the regulation of cell signaling, particularly in the context of the TGF-β signaling pathway. TGF-β is a signaling pathway that is important for the development and maintenance of tissues and organs, and it is activated in response to the presence of certain proteins, including TGF-β1. TMEM35A has been shown to be a critical component of the TGF-β signaling pathway and has been shown to play a role in the regulation of cell signaling.

TMEM35A is also involved in the regulation of cell adhesion, which is the process by which cells stick together to form tissues and organs. It is part of the cadherin family of transmembrane proteins, which includes cadherins and hercins. These proteins help to maintain the integrity of cell membranes and play a role in cell-cell adhesion. This is important for the development and maintenance of tissues and organs and is critical for the development and maintenance of tissues and organs.

TMEM35A is also involved in the regulation of cell signaling, particularly in the context of the Wnt signaling pathway. Wnt is a signaling pathway that is important for the development and maintenance of tissues and organs, and it is activated in response to the presence of certain proteins, including Wnt. TMEM35A has been shown to be a critical component of the Wnt signaling pathway and has been shown to play a role in the regulation of cell signaling.

TMEM35A is also involved in the regulation of cell signaling, particularly in the context of the TGF-β signaling pathway. TGF-β is a signaling pathway that is important for the development and maintenance of tissues and organs, and it is activated in response to the presence of certain proteins, including TGF-β1. TMEM35A has been shown to be a critical component of the TGF-β signaling pathway and has been shown to play a role in the regulation of cell signaling.

TMEM35A is also involved in the regulation of cell signaling, particularly in the context of the

Protein Name: Transmembrane Protein 35A

Functions: Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain (PubMed:26875622, PubMed:27789755, PubMed:28445721, PubMed:32204458, PubMed:32783947). Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors (PubMed:26875622, PubMed:27789755, PubMed:28445721, PubMed:32204458, PubMed:32783947). Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (By similarity). Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly (PubMed:28445721). Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (PubMed:32676916)

The "TMEM35A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM35A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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