TMEM37 as A Drug Target for Epilepsy, Heart Failure and Neurodegenerative Disorders

Target Name: TMEM37

NCBI ID: G140738

TMEM37

TMEM37 as A Drug Target for Epilepsy, Heart Failure and Neurodegenerative Disorders

TMEM37 (Transient Membrane Potential) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is involved in the regulation of ion channels and is thought to play a crucial role in the function of these organs.Recent studies have suggested that TMEM37 may be a drug target (or biomarker) for various diseases, including epilepsy, heart failure, and neurodegenerative disorders.

Epilepsy is a common neurological disorder that is characterized by the absence of normal brain activity. It is estimated that approximately 50 million people in the United States have epilepsy, and it can be a serious and debilitating condition. The exact cause of epilepsy is not known, but it is thought to involve the disruption of ion channels in the brain.TMEM37 is known to be involved in the regulation of ion channels, and it is possible that it plays a role in the development and progression of epilepsy.

Heart failure is a condition in which the heart is not able to pump enough blood to meet the body's needs. It is a serious and life-threatening condition that can lead to heart failure and other complications. The exact cause of heart failure is not known, but it is thought to involve the disruption of ion channels in the heart.TMEM37 is known to be involved in the regulation of ion channels, and it is possible that it plays a role in the development and progression of heart failure.

Neurodegenerative disorders are a group of diseases that are characterized by the progressive loss of brain cells. Some of the most common neurodegenerative disorders include Alzheimer's disease, Parkinson's disease, and Huntington's disease. These conditions are thought to involve the disruption of ion channels in the brain, and TMEM37 may be involved in their development and progression.

In conclusion, TMEM37 is a protein that is involved in the regulation of ion channels and has been suggested as a potential drug target (or biomarker) for various diseases, including epilepsy, heart failure, and neurodegenerative disorders. Further research is needed to fully understand the role of TMEM37 in these conditions and to develop effective treatments.

Protein Name: Transmembrane Protein 37

Functions: Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity)

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