TMEM74: A Potential Drug Target and Biomarker for Analyzing Membrane Transport in disease

Target Name: TMEM74

NCBI ID: G157753

TMEM74

TMEM74: A Potential Drug Target and Biomarker for Analyzing Membrane Transport in disease

Introduction

Membrane transport, the process by which molecules are transported across the membrane of a cell, plays a vital role in maintaining cellular homeostasis and exocrine function. TMEM74, Transmembrane protein 74, is a family protein that belongs to glycoprotein and is encoded as FPKM16.1. TMEM74 plays an important role in a variety of physiological processes, such as maintaining cell morphology, participating in cell signaling, and regulating intracellular transport. At the same time, it also has broad application prospects in disease diagnosis and treatment. This article will discuss the structure, function, drug targets and other aspects of TMEM74 to provide certain theoretical support for the application prospects of TMEM74 in disease research.

1. Structural features of TMEM74

TMEM74 is a transmembrane protein whose main feature is that it has six transmembrane 伪-helices. The N-terminus of TMEM74 is rich in positively charged residues (+P) such as lysine and phenylalanine, which is beneficial to binding to other charged molecules. The C-terminus of TMEM74 is rich in negatively charged residues (-N) such as alanine and asparagine, which helps maintain its stable three-dimensional structure. In addition, the central region of TMEM74 contains multiple conserved cysteines, which may be related to the hydrophilicity of the membrane protein.

2. Functional features of TMEM74

1. Participate in cell morphology maintenance

In the process of maintaining cell morphology, TMEM74 interacts with proteins such as integrins and jointly participates in receptor recognition and signal transduction processes on the cell membrane. These signaling molecules interact to give the cell membrane a certain fluidity, thus maintaining the stability of the cell shape.

2. Participate in cell signaling

TMEM74 plays an important role in cell signaling and is a key component in multiple signal transduction pathways. For example, TMEM74 can bind to protein kinase 3 (PK3) and participate in the signaling process of p21 activation in cells. At the same time, TMEM74 can also bind to calcium ions and participate in the regulation of intracellular calcium ion concentration, thereby affecting cell signaling.

3. Regulate intracellular transport

TMEM74 plays an important role in intracellular transport, such as participating in the transport of intracellular materials and intracellular phagocytosis. In addition, TMEM74 can also interact with proteins such as transport ATPase to regulate the utilization of intracellular ATP, thereby affecting the rate of intracellular transport.

3. Drug targets of TMEM74

1. TMEM74 as a drug target

At present, TMEM74 has become a hot target for multiple drug research. For example, using click chemistry synthesis, researchers successfully transformed TMEM74 into a bioactive drug by introducing specific amino acids. In addition, TMEM74 interacts with other proteins and can be used as a biomarker for multiple signal transduction pathways, providing new targets for disease diagnosis and treatment.

2. TMEM74 as a biomarker

TMEM74 has broad application prospects in disease diagnosis and treatment. For example, by detecting the expression levels of TMEM74, a patient's response to treatment can be determined. In addition, TMEM74 can also be used as a biomarker for certain diseases, such as lung cancer, liver cancer, etc. By detecting the content of TMEM74, we can provide new basis for the diagnosis and treatment of diseases.

4. Application prospects of TMEM74 in disease research

TMEM74 plays an important role in maintaining cell morphology, participating in cell signaling, and regulating intracellular transport. By studying the structure, function, drug targets and other aspects of TMEM74, it provides new theoretical basis and targets for the diagnosis and treatment of diseases. In future research, TMEM74 is expected to serve as an important drug target or biomarker, bringing new breakthroughs in the diagnosis and treatment of diseases.

Protein Name: Transmembrane Protein 74

Functions: Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction

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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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