TMEM247: A Transmembrane Protein as a Potential Drug Target and Biomarker

Target Name: TMEM247

NCBI ID: G388946

TMEM247

Other Name(s): transmembrane protein ENSP00000343375 | transmembrane protein 247 | Transmembrane protein 247 | TM247_HUMAN

TMEM247: A Transmembrane Protein as a Potential Drug Target and Biomarker

TMEM247 (transmembrane protein ENSP00000343375) is a protein that has been identified as a potential drug target and biomarker. It is a member of the ENP (endoplasmic reticulum-to-endosomal protein) family, which is characterized by the presence of a transmembrane region and various cytoplasmic domains. TMEM247 is expressed in various tissues and has been implicated in various cellular processes, including intracellular signaling, cell adhesion, and neurotransmission.

Drug Target Potential

The potential drug target for TMEM247 is its role in intracellular signaling. TMEM247 has been shown to play a role in the regulation of mitochondrial function and to influence cellular metabolism. It has been shown to interact with various cellular signaling pathways, including the PI3K/Akt signaling pathway, which is involved in cell survival, proliferation, and angiogenesis.

TMEM247 has also been shown to interact with the protein p53, which is a well-known tumor suppressor protein. The interaction between TMEM247 and p53 suggests that TMEM247 may be a potential drug target for cancer treatment.

Biomarker Potential

TMEM247 has also been shown to be a potential biomarker for various diseases, including neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. The interaction between TMEM247 and dopamine, a neurotransmitter involved in these disorders, suggests that TMEM247 may be a potential biomarker for these conditions.

Expression and Localization

TMEM247 is expressed in various tissues, including brain, heart, and pancreas. It is primarily located in the endoplasmic reticulum (ER) and is involved in the delivery of endoplasmic reticulum-exiting proteins (ERs) to the cytoplasm. TMEM247 has also been shown to be involved in the delivery of other proteins to the ER, including proteins involved in cell adhesion and neurotransmission.

TMEM247 localization to the ER and its involvement in the delivery of proteins to the cytoplasm suggest that it may be a potential drug target for diseases that involve disruptions in ER-to-cytoplasmic protein delivery, such as neurodegenerative disorders.

Conclusion

TMEM247 is a transmembrane protein that has been shown to play a role in various cellular processes, including intracellular signaling and protein delivery to the endoplasmic reticulum. Its potential drug target potential and biomarker properties make it an attractive target for future research. Further studies are needed to fully understand the role of TMEM247 in cellular processes and its potential as a drug or biomarker.

Protein Name: Transmembrane Protein 247

The "TMEM247 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM247 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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