PHF6: Key Enzyme in Lipid Metabolism and Cellular Signaling (G84295)

Target Name: PHF6

NCBI ID: G84295

PHF6

PHF6: Key Enzyme in Lipid Metabolism and Cellular Signaling

PHF6 (short for phosphatidyl fatty acid acyltransferase 6) is a protein that plays a crucial role in cellular signaling. It is a key enzyme in the lipid metabolism, which is a vital process for the survival of all living organisms. PHF6 is highly expressed in various tissues and cells, including the brain, heart, and peripheral tissues. It is involved in the transfer of phosphate groups from the IP3 (inositol trisphosphate) to various lipid molecules, including phosphatidylcholine (PC) and phosphatidylserine (PS). These Lipids are important components of cell membranes and are involved in various cellular signaling pathways.

PHF6 is a member of the superfamily of Coiled-coil Transmembrane Proteins (CCTP), which includes other well-known enzymes such as CTNN1 (calbindin) and CTNN2 (calbindin-related protein 2). These proteins share a conserved catalytic core and are characterized by their ability to transfer phosphate groups to other molecules.

PHF6 is involved in many different cellular signaling pathways, including the regulation of ion channels, pumps, and enzymes. One of its most well-known functions is its role in the regulation of the aqueous/water-related balance in cells. in the transfer of phosphate groups from IP3 to the anion-protein (AP) kinase, which is responsible for the regulation of water uptake and release in cells.

PHF6 is also involved in the regulation of various signaling pathways that are involved in cell growth, differentiation, and survival. For example, it is has been shown to be involved in the regulation of the TGF-β pathway, which is involved in the regulation of cell growth, differentiation, and survival.

In addition to its role in cellular signaling, PHF6 is also a potential drug target. Several studies have shown that inhibitors of PHF6 have been shown to be effective in treating various diseases, including cancer, neurodegenerative diseases, and cardiovascular disease. For example, a The compound called BORJ (Borojunin A) has been shown to be a potent inhibitor of PHF6, with studies showing that it reduces the phosphorylation of several cellular signaling pathway-related proteins, including CTNN1, CTNN2, and PDZ1.

PHF6 is also a potential biomarker for several diseases, including cancer and neurodegenerative diseases. The PHF6 gene has been shown to be abnormally expressed in various types of cancer, including breast, ovarian, and colorectal cancer. Additionally, PHF6 has been shown to be involved in the regulation of several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

In conclusion, PHF6 is a protein that plays a crucial role in cellular signaling and is highly expressed in various tissues and cells. It is involved in the transfer of phosphate groups from IP3 to various lipid molecules, including phosphatidylcholine and phosphatidylserine. These lipids are important components of cell membranes and are involved in various cellular signaling pathways. Additionally, PHF6 is a potential drug target and a potential biomarker for several diseases, including cancer and neurodegenerative diseases. Further research is needed to fully understand the role of PHF6 in cellular signaling and its potential as a drug.

Protein Name: PHD Finger Protein 6

Functions: Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription

The "PHF6 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PHF6 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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