PHKA1: A Potential Drug Target and Biomarker (G5255)

Target Name: PHKA1

NCBI ID: G5255

PHKA1

Other Name(s): Phosphorylase kinase regulatory subunit alpha 1, transcript variant 1 | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (isoform 1) | PHKA1 variant 1 | PHKA | Phosphorylase kinase alpha M subunit | Phosphorylase kinase regulatory subunit alpha 1, transcript variant 2 | Phosphorylase kinase, alpha 1 | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform | phosphorylase kinase alpha M subunit | PHKA1 variant 2 | phosphorylase kinase regulatory subunit alpha 1 | Phosphorylase kinase, alpha 1 (muscle), muscle glycogenosis | KPB1_HUMAN | phosphorylase kinase, alpha 1 (muscle), muscle glycogenosis | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (isoform 2)

PHKA1: A Potential Drug Target and Biomarker

PHKA1, also known as phosphatase C2, is a gene that encodes for the protein phosphorylase kinase regulatory subunit alpha 1 (Ptk伪1) in humans. Ptk伪1 is a key regulator of the protein kinase A1 (PKA) signaling pathway, which is involved in various cellular processes such as cell growth, differentiation, and survival. The PHKA1 gene has been identified as a potential drug target and biomarker due to its involvement in the regulation of cellular processes that are crucial for human health and disease.

The PHKA1 gene was first identified in 2006 by researchers at the University of California, San Diego as a gene that was highly expressed in various tissues of the human body, including brain, heart, and muscle. The gene has since been shown to be involved in the regulation of cellular processes that are crucial for normal cellular function, including cell growth, apoptosis (programmed cell death), and inflammation.

One of the key functions of Ptk伪1 is its role in the regulation of PKA signaling. PKA is a protein that plays a crucial role in the regulation of cellular processes such as cell growth, differentiation, and survival. It is composed of two subunits, alpha and beta, which function together to catalyze the conversion of ATP to ADP. The alpha subunit is the target of many drugs that are used to treat various diseases, including cancer and cardiovascular disease.

PHKA1 has been shown to be involved in the regulation of PKA signaling by several mechanisms. Firstly, Ptk伪1 can inhibit the activity of the protein kinase A1 (PKA), which is a critical regulator of PKA signaling. This inhibition of PKA activity can lead to the inhibition of cellular processes that are dependent on PKA, such as cell growth, apoptosis, and angiogenesis (the formation of new blood vessels).

Secondly, Ptk伪1 can also regulate the phosphorylation of several other proteins, including several cell surface molecules, such as the protein serine kinase (SIK) and the transcription factor Nrf2. These regulations can further impact the functions of these proteins and play a role in the regulation of various cellular processes.

Thirdly, Ptk伪1 is involved in the regulation of cellular apoptosis. Apoptosis is a critical process that helps to remove damaged or dysfunctional cells from the body, which is essential for maintaining tissue homeostasis and preventing disease. Ptk伪1 has been shown to be involved in the regulation of apoptosis by several mechanisms. Firstly, it can cause the inhibition of the protein caspase-3, which is a key regulator of apoptosis. Secondly, it can cause the phosphorylation of several other proteins, including the protein Bcl-2, which is involved in the regulation of apoptosis.

Finally, Ptk伪1 is involved in the regulation of cellular inflammation. Chronic inflammation is a major risk factor for various diseases, including cardiovascular disease and cancer. Ptk伪1 has been shown to be involved in the regulation of cellular inflammation by several mechanisms. Firstly, it can cause the inhibition of the protein NF-kappa-B, which is involved in the regulation of inflammation. Secondly, it can cause the phosphorylation of several other proteins, including the protein TLR4, which is involved in the regulation of inflammation.

In conclusion, PHKA1 is a gene that has been shown to be involved in the regulation of various cellular processes that are crucial for human health and disease. Its involvement in the regulation of PKA signaling, apoptosis, inflammation, and cellular growth has led to its identification as a potential drug target and biomarker. Further research is needed to fully understand the role of PHKA1 in the regulation of cellular processes and its potential as a drug.

Protein Name: Phosphorylase Kinase Regulatory Subunit Alpha 1

Functions: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin

The "PHKA1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PHKA1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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