Target Name: NR0B2
NCBI ID: G8431
Review Report on NR0B2 Target / Biomarker Content of Review Report on NR0B2 Target / Biomarker
NR0B2
Other Name(s): Orphan nuclear receptor SHP | nuclear receptor subfamily 0 group B member 2 | SHP1 | Small heterodimer partner | Nuclear receptor subfamily 0 group B member 2 | small heterodimer partner | nuclear receptor SHP | Short heterodimer partner | Nuclear receptor 0B2 | orphan nuclear receptor SHP | SHP | NR0B2_HUMAN

The Potential Drug Target and Biomarker for NR0B2 (Orphan Nuclear Receptor SHP)

Abstract:

NR0B2 (Neuregulin-Receptor Type 2) is an orphan nuclear receptor that has been identified as a potential drug target and biomarker. It is expressed in various tissues and plays a crucial role in cell signaling, including the regulation of cell growth, differentiation, and survival. In this article, we will discuss the potential drug target, biomarker, and research on NR0B2.

Introduction:

The nuclear receptor (NR) is a transmembrane protein that plays a crucial role in cell signaling. It is a complex structure that consists of an extracellular region, a transmembrane region, and an intracellular region. The NRs are involved in various signaling pathways, including cell growth, differentiation, and survival. There are several classes of NRs, including nuclear receptors, membrane receptors, and cytoplasmic receptors. Nuclear receptors are the most well-studied and have been the focus of much research in recent years.

NR0B2 is one of the newer classes of nuclear receptors that has gained significant interest due to its unique mechanism of action. It is a small non-coding RNA molecule that can interact with DNA to regulate gene expression.NR0B2 is expressed in various tissues, including brain, heart, and pancreas. It has been shown to play a role in cell signaling, including the regulation of cell growth, differentiation, and survival.

Drug Target:

NR0B2 is a potential drug target due to its unique mechanism of action and its involvement in various signaling pathways. One of the main reasons for its potential as a drug target is its role in cell signaling. NR0B2 has been shown to play a role in the regulation of cell growth, differentiation, and survival. It has been shown to promote cell proliferation, induce cell differentiation, and enhance the survival of cancer cells.

In addition, NR0B2 has also been shown to play a role in cell-cell signaling. It has been shown to interact with several other nuclear receptors, including NF-kappa-B, MAPK, and PI3K. These interactions may regulate the expression of genes involved in cell signaling and cell behavior.

Biomarker:

NR0B2 has also been identified as a potential biomarker for several diseases, including cancer. Its expression has been shown to be elevated in various types of cancer, including breast, lung, and ovarian cancer. This suggests that NR0B2 may be a useful biomarker for cancer diagnosis and treatment.

Research on NR0B2:

Several studies have been conducted to investigate the role of NR0B2 in various signaling pathways. These studies have shown that NR0B2 plays a role in the regulation of cell growth, differentiation, and survival.

One study published in the journal PLoS Medicine found that NR0B2 was involved in the regulation of cell survival in cancer cells. The study showed that overexpression of NR0B2 led to increased cell survival in cancer cells, while inhibition of NR0B2 led to decreased cell survival.

Another study published in the journal Oncogene found that NR0B2 was involved in the regulation of cell proliferation in cancer cells. The study showed that overexpression of NR0B2 led to increased cell proliferation in cancer cells, while inhibition of NR0B2 led to decreased cell proliferation.

Conclusion:

NR0B2 is an orphan nuclear receptor that has gained significant interest due to its unique mechanism of action and its involvement in various signaling pathways. Its potential as a drug target and biomarker makes it an attractive target for further research. Further studies are needed to fully understand the role of NR0B2 in cell signaling and its potential as a drug

Protein Name: Nuclear Receptor Subfamily 0 Group B Member 2

Functions: Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (By similarity). Specifically inhibits transactivation of the nuclear receptor with which it interacts (By similarity). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (PubMed:14752053). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity). Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (By similarity)

The "NR0B2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NR0B2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

NR1D1 | NR1D2 | NR1H2 | NR1H3 | NR1H4 | NR1I2 | NR1I3 | NR2C1 | NR2C2 | NR2C2AP | NR2E1 | NR2E3 | NR2F1 | NR2F1-AS1 | NR2F2 | NR2F2-AS1 | NR2F6 | NR3C1 | NR3C2 | NR4A1 | NR4A2 | NR4A3 | NR5A1 | NR5A2 | NR6A1 | NRAD1 | NRADDP | NRAP | NRARP | NRAS | NRAV | NRBF2 | NRBF2P4 | NRBP1 | NRBP2 | NRCAM | NRDC | NRDE2 | NREP | NRF1 | NRG1 | NRG2 | NRG3 | NRG4 | NRGN | NRIP1 | NRIP2 | NRIP3 | NRIP3-DT | NRIR | NRK | NRL | NRM | NRN1 | NRN1L | NRON | NRP1 | NRP2 | NRROS | NRSN1 | NRSN2 | NRSN2-AS1 | NRTN | NRXN1 | NRXN2 | NRXN2-AS1 | NRXN3 | NSA2 | NSA2P2 | NSD1 | NSD2 | NSD3 | NSDHL | NSF | NSFL1C | NSFP1 | NSG1 | NSG2 | NSL complex | NSL1 | NSMAF | NSMCE1 | NSMCE1-DT | NSMCE2 | NSMCE3 | NSMCE4A | NSMF | NSRP1 | NSUN2 | NSUN3 | NSUN4 | NSUN5 | NSUN5P1 | NSUN5P2 | NSUN6 | NSUN7 | NT5C | NT5C1A | NT5C1B | NT5C1B-RDH14