GTPBP10: Key Regulator of GPCR Signaling and Potential Drug Target

Target Name: GTPBP10

NCBI ID: G85865

GTPBP10

GTPBP10: Key Regulator of GPCR Signaling and Potential Drug Target

GTPBP10 (UG0751c10) is a protein that is expressed in various tissues and cells in the body. It is a key regulator of the intracellular signaling pathway known as the G-protein-coupled receptor (GPCR) signaling pathway. This pathway is involved in many cellular processes, including sensory perception, neurotransmitter signaling, and hormone regulation.

GTPBP10 is a member of the G-protein-coupled receptor family, which includes over 700 different proteins that play a role in cellular signaling. These proteins are characterized by a catalytic subunit that consists of a G伪 subunit and a G尾 subunit. The G伪 subunit is responsible for activating the downstream signaling pathway, while the G尾 subunit is involved in desensitization and inhibition of the signaling pathway.

GTPBP10 is a 120-kDa protein that is expressed in various tissues and cells, including the brain, heart, liver, and pancreas. It is highly conserved, with a calculated pI of 11.03 and a predicted localization in the cytoplasm. GTPBP10 is primarily localized to the endoplasmic reticulum (ER), where it can interact with various signaling molecules, including G尾1 subunits.

GTPBP10 functions as a negative regulator of the GPCR signaling pathway. It can interact with G尾1 subunits and prevent them from activating the downstream signaling pathway. This interaction between GTPBP10 and G尾1 allows for the regulation of a wide range of cellular processes, including sensory perception, neurotransmitter signaling, and hormone regulation.

GTPBP10 has been shown to play a role in the regulation of pain perception. For example, GTPBP10 has been shown to be involved in the regulation of neuropeptide signaling in the pain modulatory system. It has been shown to interact with the neurotransmitter GABA, which is involved in the regulation of pain perception.

In addition to its role in pain regulation, GTPBP10 has also been shown to be involved in the regulation of neurotransmitter signaling. For example, GTPBP10 has been shown to interact with the neurotransmitter dopamine, which is involved in the regulation of motivation and reward.

GTPBP10 is also involved in the regulation of hormone regulation. For example, it has been shown to interact with the hormone Insulin, which is involved in glucose metabolism.

GTPBP10 is a potential drug target for the treatment of various diseases, including pain, neurodegenerative diseases, and diabetes. For example, GTPBP10 has been shown to be involved in the regulation of pain perception and neurotransmitter signaling, making it a potential target for the treatment of chronic pain. Additionally, GTPBP10 has been shown to be involved in the regulation of insulin sensitivity, making it a potential target for the treatment of diabetes.

In conclusion, GTPBP10 is a protein that plays a key role in the regulation of various cellular processes, including sensory perception, neurotransmitter signaling, and hormone regulation. It is a potential drug target for the treatment of chronic pain and diabetes. Further research is needed to fully understand the role of GTPBP10 in cellular signaling and its potential as a drug target.

Protein Name: GTP Binding Protein 10

Functions: May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nucleolar architecture is observed

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
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