TMEM203: A Potential Drug Target and Biomarker for Membrane Proteins

Target Name: TMEM203

NCBI ID: G94107

TMEM203

TMEM203: A Potential Drug Target and Biomarker for Membrane Proteins

Introduction

Membrane proteins are an essential component of various biological processes, including signal transduction, material transport, and cell recognition. TMEM203 (Transmembrane Protein 203), also known as TMEM-Ts, is a member of the transmembrane protein (TMEM) family that characterized by the presence of a transmembrane region and cytoplasmic N-terminus. TMEM203 is expressed in various cell types and plays a crucial role in cell signaling, protein transport, and cell-cell adhesion.

TMEM203 is a potential drug target due to its unique structure and its involvement in various cellular processes. The TMEM203 protein has been shown to interact with various protein partners, including tyrosine kinases, G protein-coupled receptors, and integrins. These interactions suggest that TMEM203 could be a useful target for small molecules or antibodies that can modulate its activity.

In addition to its potential as a drug target, TMEM203 has also been identified as a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. The unique expression patterns of TMEM203 in different tissues and the presence of TMEM203 gene fusions in various cancer types make it an attractive marker for cancer diagnosis and treatment.

TMEM203 Expression and Localization

TMEM203 is expressed in various cell types, including neurons, endothelial cells, and epithelial cells. Its expression is highly dependent on the cell type and context, such as cell type, tissue, and developmental stage. For example, TMEM203 is highly expressed in brain and spinal cord tissue, where it is involved in the development and maintenance of the nervous system.

TMEM203 is primarily localized to the endoplasmic reticulum (ER) and is predominantly targeted to the transmembrane region. The cytoplasmic region of TMEM203 is relatively short and does not appear to play a significant role in its localization. The ER-associated degradation (ERAD) pathway is known to be involved in the delivery ofTMEM203 to the ER, where it can be targeted to specific protein localizing regions within the ER.

TMEM203 Interactions with Protein Partners

TMEM203 has been shown to interact with various protein partners, including tyrosine kinases, G protein-coupled receptors, and integrins. The most well-known interaction is with the tyrosine kinase PDGFR-尾, which is part of the PDGFR signaling pathway. The interaction between TMEM203 and PDGFR-尾 has been shown to play a role in cell signaling, including the regulation of cell growth, differentiation, and survival.

Another interaction of TMEM203 is with G protein-coupled receptors (GPCRs), which are a family of transmembrane proteins that play a critical role in cellular signaling. TMEM203 has been shown to interact with several GPCRs, including the erbB2 receptor, which is involved in the regulation of cell growth, differentiation, and survival.

In addition to its interactions with GPCRs, TMEM203 has also been shown to interact with integrins, which are a family of transmembrane proteins that play a critical role in cell-cell adhesion. The interaction between TMEM203 and integrins has been shown to be involved in the regulation of cell-cell adhesion, including the regulation of cell migration and the formation of tight junctions.

TMEM203 as a Drug Target

The potential drug targeting of TMEM203 is based on its unique structure and its involvement in various cellular processes. TMEM203 has been shown to interact

Protein Name: Transmembrane Protein 203

Functions: Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873)

The "TMEM203 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM203 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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