HERPUD1: Homocysteine-Responsive Endoplasmic Reticulum-Resident Ubiquitin-Like Domain Member 1

Target Name: HERPUD1

NCBI ID: G9709

HERPUD1

Other Name(s): Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein | MIF1 | HERP | HERPUD1 variant 1 | Mif1 | MMS-inducible | KIAA0025 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | homocysteine inducible ER protein with ubiquitin like domain 1 | homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 protein | Methyl methanesulfonate (MMF)-inducible fragment protein 1 | Homocysteine inducible ER protein with ubiquitin like domain 1, transcript variant 1 | Homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 protein | methyl methanesulfonate (MMF)-inducible fragment protein 1 | HERP1_HUMAN | SUP

HERPUD1: Homocysteine-Responsive Endoplasmic Reticulum-Resident Ubiquitin-Like Domain Member 1

HERPUD1: A Potential Drug Target and Biomarker for Homocysteine-Responsive Endoplasmic Reticulum-Resident Ubiquitin-Like Domain Member 1

Abstract:

HERPUD1, a member of the ubiquitin-like domain family, has been identified as a potential drug target and biomarker for the treatment of various diseases, including neurodegenerative disorders, cancer, and autoimmune diseases. Its unique function as an endoplasmic reticulum-resident protein and its ability to interact with various biomolecules, including homocysteine, make it an attractive candidate for drug development. In this article, we will provide an overview of HERPUD1, its functions, and potential drug targets.

Introduction:

The endoplasmic reticulum (ER) is a complex organelle that plays a crucial role in the regulation of protein synthesis and degradation. It is the final destination for many proteins, including ubiquitin-like domain (ULD) proteins, which are involved in various cellular processes. One of these proteins is HERPUD1, a member of the ULD family that is characterized by the presence of a unique N-terminal region containing a homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain (HERPUD1-ER-ULD).

HERPUD1 Functions:

HERPUD1 functions as an endoplasmic reticulum-resident protein, which means it remains in the ER for a significant period and is involved in various cellular processes. It plays a critical role in the regulation of protein synthesis, degradation, and quality control.

One of the most significant functions of HERPUD1 is its ability to interact with homocysteine (Hcy), a small molecule that is known to play a crucial role in the regulation of gene expression and protein synthesis. Hcy can also interact with HERPUD1, leading to the formation of a complex that can affect the stability and localization of HERPUD1.

HERPUD1 also interacts with other proteins, including ubiquitin, which is a well-known protein involved in the regulation of protein degradation. The interaction between HERPUD1 and ubiquitin can modulate the stability and localization of both proteins, which may have implications for their functions in various cellular processes.

Potential Drug Targets:

HERPUD1's unique functions as an endoplasmic reticulum-resident protein make it an attractive candidate for drug development. Several studies have identified potential drug targets for HERPUD1, including the regulation of protein synthesis and degradation, quality control, and the modulation of cellular processes.

One of the most promising drug targets for HERPUD1 is its role in the regulation of protein synthesis and degradation. Several studies have shown that HERPUD1 can interact with ubiquitin and other proteins involved in protein synthesis and degradation. This interaction suggests that HERPUD1 may be a useful target for drugs that can modulate the stability and localization of these proteins.

Another potential drug target for HERPUD1 is its role in the regulation of quality control. HERPUD1 has been shown to interact with the protein quality control system, which is responsible for ensuring the stability and quality of proteins. This interaction suggests that HERPUD1 may be a useful target for drugs that can modulate the quality control process and improve protein stability.

In addition to its potential drug targets, HERPUD1 may also be a useful biomarker for various diseases. As mentioned earlier, HERPUD1 functions as an endoplasmic reticulum-resident protein, which means it remains in the ER for a significant period and is involved in various cellular processes. This suggests that HERPUD1 may be a useful biomarker for diseases associated with endoplasmic reticulum dysfunction, such as neurodegenerative disorders, cancer, and autoimmune diseases.

Conclusion:

In conclusion, HERPUD1 is a unique protein that functions as an endoplasmic reticulum-resident protein with the ability to interact with various biomolecules, including homocysteine. Its unique function and potential drug targets make it an attractive candidate for drug development and as a biomarker for various diseases. Further research is needed to fully understand the functions of HERPUD1 and its potential as a drug

Protein Name: Homocysteine Inducible ER Protein With Ubiquitin Like Domain 1

Functions: Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16289116, PubMed:28827405). Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982)

The "HERPUD1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HERPUD1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets