HS3ST3A1: A Potential Drug Target for Hematological Diseases (G9955)

Target Name: HS3ST3A1

NCBI ID: G9955

HS3ST3A1

HS3ST3A1: A Potential Drug Target for Hematological Diseases

HS3ST3A1, also known as H3-OST-3A, is a protein that is expressed in various tissues throughout the body. It is a key regulator of the hematopoietic stem cell (HSC) lineage and has been identified as a potential drug target in the field of hematological diseases.

The HSC is a specialized type of stem cell that gives rise to all blood cells, including red blood cells, white blood cells, and platelets. HSCs have the ability to self-renew and differentiate into different cell types, making them a promising source of cancer therapies. However, the development and maintenance of HSCs is a complex process that is not fully understood.

HS3ST3A1 is a non-coding RNA molecule that has been shown to regulate the self-renewal and differentiation of HSCs. It is a key regulator of the p53 gene, which is a well-known tumor suppressor gene that plays a critical role in preventing the development and progression of cancer.

studies have shown that HS3ST3A1 can inhibit the self-renewal ability of HSCs by targeting the p53 gene. This can lead to a reduction in the number of HSCs that have the ability to divide and multiply, which can potentially lead to a reduction in the risk of developing cancer.

Additionally, HS3ST3A1 has also been shown to play a role in the regulation of cell survival and the transition of cells to apoptosis. This is important because the regulation of cell survival and apoptosis is a critical aspect of the immune system and has been implicated in a number of diseases, including cancer.

In conclusion, HS3ST3A1 is a protein that has the potential to be a drug target in the field of hematological diseases. Further research is needed to fully understand its role in the regulation of HSCs and its potential as a therapeutic agent.

Protein Name: Heparan Sulfate-glucosamine 3-sulfotransferase 3A1

Functions: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate (PubMed:10520990, PubMed:9988768, PubMed:10608887, PubMed:15304505). Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2 (PubMed:10520990, PubMed:9988768, PubMed:15304505). The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry (PubMed:10520990). Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (PubMed:10520990)

The "HS3ST3A1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HS3ST3A1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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