ATP6V0D1-DT: A Promising Drug Target and Biomarker (G101927837)

Target Name: ATP6V0D1-DT

NCBI ID: G101927837

ATP6V0D1-DT

Other Name(s): ATP6V0D1 divergent transcript | LOC101927837 | Uncharacterized LOC101927837

ATP6V0D1-DT: A Promising Drug Target and Biomarker

ATP6V0D1, also known as ATP6V0D1-DT, is a protein that is expressed in various tissues and cell types in the human body. It plays a crucial role in the regulation of cell signaling, DNA replication, and repair, and has been implicated in the development and progression of numerous diseases, including cancer. As a result, ATP6V0D1 has emerged as a promising drug target and biomarker for a variety of therapeutic applications.

The Discovery and Characterization of ATP6V0D1

ATP6V0D1 was first identified as a gene encoding a protein with 6 transmembrane spans and a N-terminus that contains a conserved ATP-binding site. The protein encoded by this gene has been shown to play a critical role in the regulation of DNA replication and repair, as well as cell signaling pathways.

To further understand the function of ATP6V0D1, researchers used a variety of techniques, including biochemical, cellular, and mass spectrometry studies, to characterize the protein. These studies have provided valuable insights into the protein's structure, function, and regulation.

The Potential Therapeutic Applications of ATP6V0D1

The potential therapeutic applications of ATP6V0D1 are vast and varied. As a drug target, ATP6V0D1 has been shown to be involved in a wide range of cellular processes, including cell signaling, DNA replication, and repair, making it an attractive target for small molecule inhibitors. Additionally, the protein has been implicated in the development and progression of a variety of diseases, including cancer, which further supports its potential as a biomarker for disease diagnosis and prognosis.

In addition to its therapeutic applications, ATP6V0D1 also has significant potential as a biomarker. The protein is expressed in a variety of tissues and cell types, including the brain, heart, and gastrointestinal tract, making it a potential biomarker for a variety of diseases. Additionally, the protein has been shown to be expressed in a variety of cancer types, which further supports its potential as a biomarker for cancer diagnosis and treatment.

The ATP6V0D1-DT Structure and Function

The structure and function of ATP6V0D1 have been studied extensively, and the protein has been shown to have a conserved ATP-binding site that is critical for its function. This site is located at the N-terminus of the protein and consists of a region that is known as the N-terminal domain. This domain is responsible for the protein's ability to bind to ATP and for its role in regulating cellular processes, including DNA replication and repair.

In addition to its conserved ATP-binding site, ATP6V0D1 has several other unique features that have implications for its function. The protein has a variable region that is highly conserved across different species, which suggests that it has a role in the regulation of essential cellular processes. Additionally, the protein has a propensity to localize to the endoplasmic reticulum (ER), which is a site of protein synthesis and degradation, suggesting that it may have a role in regulating the delivery and degradation of proteins in the cell.

The Role of ATP6V0D1 in Cellular Signaling

ATP6V0D1 is involved in a wide range of cellular signaling pathways, including those that regulate cell growth, differentiation, and survival. One of its most well-studied functions is its role in the regulation of cell proliferation. In cell culture studies, researchers have shown that inhibitors of ATP6V0D1 can inhibit the growth of a variety of cancer cell lines, including breast, lung, and colon cancer cells.

In addition to its role in cell proliferation, ATP6V0D1 is also involved in the regulation of cell apoptosis, which is a natural mechanism of cell death that is important for the regulation of cellular

Protein Name: ATP6V0D1 Divergent Transcript

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