Unlocking the Potential of APPBP2: A Potential Drug Target and Biomarker

Target Name: APPBP2

NCBI ID: G10513

APPBP2

Unlocking the Potential of APPBP2: A Potential Drug Target and Biomarker

Amyloid protein-binding protein 2 (APPBP2) is a transmembrane protein that plays a crucial role in the regulation of various cellular processes. It is highly expressed in the brain and has been implicated in the development and progression of various neurological disorders, including Alzheimer's disease. As a result, targeting APPBP2 has the potential to offer new therapeutic approaches for the treatment of these debilitating conditions.

Disease-Related Importance

Alzheimer's disease is a well-known neurodegenerative disorder that is characterized by the accumulation of amyloid peptides and neurofibrillary tangles in the brain. The most common cause of Alzheimer's disease is the presence of APPBP2, which has been shown to contribute to the development and progression of the disease.

The accumulation of APPBP2 in the brain is associated with increased levels of beta-amyloid peptides, which are derived from theAPPB protein. beta-amyloid peptides are known to play a crucial role in the development of neurofibrillary tangles and amyloid plaques, which are the hallmark hallmarks of Alzheimer's disease.

APPBP2 as a Drug Target

The potential of APPBP2 as a drug target is high due to its unique biology and the various cellular processes that it regulates. One of the key advantages of APPBP2 is its high expression in the brain, which makes it an attractive target for small molecules. Additionally, its transmembrane nature and its role in regulating various cellular processes also enhance its potential as a drug target.

APPBP2 has been shown to play a role in various cellular processes, including the regulation of synaptic plasticity, neurotransmitter release, and inflammation. It has also been shown to be involved in the regulation of the blood-brain barrier, which is a critical barrier that keeps many harmful substances out of the brain.

In addition to its role in cellular processes, APPBP2 has also been shown to play a role in the development of neurofibrillary tangles and amyloid plaques. Studies have shown that APPBP2 can interact with beta-amyloid peptides and contribute to their accumulation in the brain.

APPBP2 as a Biomarker

APPBP2 has also been shown to be a potential biomarker for the diagnosis and monitoring of Alzheimer's disease. The accumulation of beta-amyloid peptides and neurofibrillary tangles in the brain is a well-established hallmark of the disease, and the presence of APPBP2 in the brain may be an indicator of the disease.

In addition to its potential as a drug target, APPBP2 has also been shown to be a potential biomarker for Alzheimer's disease. Studies have shown that the level of APPBP2 is significantly decreased in individuals with Alzheimer's disease compared to age-matched control individuals. Additionally, individuals with Alzheimer's disease had lower levels of beta-amyloid peptides compared to control individuals.

Conclusion

In conclusion, APPBP2 is a protein that plays a crucial role in the regulation of various cellular processes and has been implicated in the development and progression of Alzheimer's disease. Its potential as a drug target and biomarker make it an attractive target for research into the treatment of these debilitating conditions. Further studies are needed to fully understand the role of APPBP2 in the development and progression of Alzheimer's disease and to develop new therapeutic approaches.

Protein Name: Amyloid Beta Precursor Protein Binding Protein 2

Functions: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:29775578). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:29775578). The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:29775578). The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron (PubMed:26138980). May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface (PubMed:9843960)

The "APPBP2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about APPBP2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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