MTHFS: Key Enzyme in Folate Metabolism (G10588)

Target Name: MTHFS

NCBI ID: G10588

MTHFS

MTHFS: Key Enzyme in Folate Metabolism

MTHFS, or 5-formyltetrahydrofolate cyclo-ligase, is a enzyme involved in the metabolism of folate, a B vitamin that is essential for the growth and development of the human body. MTHFS is a key enzyme in the synthesis of 5-formyltetrahydrofolate, a crucial coenzyme for the metabolism of tryptophan, another important B vitamin. MTHFS plays a crucial role in the production of tryptophan from tryptophan hydroxylase, which is the first step in the synthesis of tryptophan from tryptophan hydroxylase (Tph1) and methenyltetrahydrofolate (MTHF), which is then converted to 5-formyltetrahydrofolate by MTHFS.

MTHFS is a member of the cyclohexane ring-transferase family 1 (CHTF2) and is located on the X chromosome. It consists of 214 amino acid residues and has a calculated molecular weight of 30 kDa. MTHFS has a single substrate, 5-formyltetrahydrofolate, and has a catalytic center consisting of a nucleotide base, a carbon atom, and a side chain.

MTHFS is involved in the synthesis of tryptophan, which is a critical coenzyme for the metabolism of many important molecules in the body. Tryptophan is involved in the production of proteins, neurotransmitters, and other molecules that are essential for the growth and development of the body. MTHFS is also involved in the metabolism of other molecules, including nucleotides, purines, and xenobiotics.

MTHFS is a potential drug target because of its involvement in the synthesis of tryptophan, which is often deficient in individuals with certain genetic disorders. For example, individuals with the genetic disorder phenylketonuria (PKU) have defective MTHFS and are unable to produce adequate levels of tryptophan, which can lead to a range of health problems, including vision problems, hearing loss, and a decreased immune system.

In addition to its involvement in tryptophan metabolism, MTHFS is also a potential biomarker for several diseases. For example, individuals with MTHFS mutations have been shown to have increased risk of developing certain types of cancer, including breast and ovarian cancer. Additionally, individuals with MTHFS mutations have been shown to have decreased levels of tryptophan and increased levels of other molecules in their bodies, which may be indicative of certain diseases.

MTHFS is also involved in the synthesis of other molecules that are important for the growth and development of the body. For example, MTHFS is involved in the synthesis of nucleotides, which are the building blocks of DNA and RNA, as well as in the synthesis of purines, which are important for the growth and development of cells. MTHFS is also involved in the metabolism of other molecules, including xenobiotics, which are molecules that can have harmful effects on the body if consumed in excess.

In conclusion, MTHFS is a key enzyme involved in the metabolism of folate, a crucial B vitamin that is essential for the growth and development of the human body. MTHFS plays a crucial role in the production of tryptophan, which is a critical coenzyme for the metabolism of many important molecules in the body. MTHFS is also involved in the synthesis of other important molecules, including nucleotides and purines, and is a potential drug target and biomarker for several diseases. Further research is needed to fully understand the role of MTHFS in the body and its potential as a drug target and biomarker.

Protein Name: Methenyltetrahydrofolate Synthetase

Functions: Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate

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