ZFAND2B: A Promising Drug Target and Potential Representative Biomarker for Airway Neuron-Induced Inflammation

Target Name: ZFAND2B

NCBI ID: G130617

ZFAND2B

ZFAND2B: A Promising Drug Target and Potential Representative Biomarker for Airway Neuron-Induced Inflammation

Abstract:

ZFAND2B, a member of the Z-protein family, has been identified as a potential drug target and biomarker for airway representative neuron-induced inflammation. Airway representation neurons (ARNS) play a crucial role in modulating inflammatory responses in the lungs, and dysfunction in these neurons have been implicated in various respiratory diseases, including chronic obstructive pulmonary disease (COPD) and asthma. ZFAND2B has been shown to regulate the activity of ARNS, which may provide new insights into its potential as a therapeutic agent.

Introduction:

Chronic obstructive pulmonary disease (COPD) and asthma are two of the leading chronic diseases worldwide, affecting millions of people worldwide, respectively. These conditions are characterized by persistent airway inflammation and progressive lung damage, leading to reduced quality of life and increased morbidity. The conditions are characterized by persistent airway inflammation and progressive lung damage, leading to reduced quality of life and increased morbidity. The underlying causes of COPD and asthma are not fully understood, but they are thought to involve an imbalance in the regulation of inflammatory responses.

Airway representation neurons (ARNS) are a subset of neurons that project to the lungs and play a critical role in modulating inflammatory responses in the airways. These neurons are responsible for producing pro-inflammatory cytokines, such as chemokines and eicosanoids, which are involved in the recruitment of immune cells and the regulation of immune cell function. Dysfunction in these neurons has been implicated in the development and progression of various respiratory diseases, including COPD and asthma.

ZFAND2B: A Potential Drug Target and Biomarker

ZFAND2B, a member of the Z-protein family, has been identified as a potential drug target and biomarker for airway representative neuron-induced inflammation. ZFAND2B is a 21-kDa protein that is expressed in various tissues, including lung, spleen, and brain . It is highly homogeneous and has been shown to have multiple functions, including the regulation of inflammation, cell survival, and neurotransmission.

ZFAND2B has been shown to regulate the activity of airway representation neurons (ARNS), which are a subset of neurons that project to the lungs and play a critical role in modulating inflammatory responses in the airways. ARNS are involved in the production of pro-inflammatory cytokines and play a crucial role in the recruitment of immune cells and the regulation of immune cell function. Dysfunction in these neurons has been implicated in the development and progression of various respiratory diseases, including COPD and asthma.

ZFAND2B is involved in the regulation of ARNS through a complex signaling cascade that involves the transcription factor, NF-kappa-B signaling pathway, and the downstream signaling pathways, including the TGF-β pathway. ZFAND2B has been shown to physically interact with ARNS and regulate its activity through the inhibition of the nuclear factor NF-kappa-B signaling pathway.

In addition to its role in regulating ARNS, ZFAND2B has also been shown to have other functions, including the regulation of cell survival, neurotransmission, and inflammation. ZFAND2B has been shown to play a role in the regulation of cell survival by promoting the expression of the anti-apoptotic protein, Bcl-2. It has also been shown to regulate neurotransmission by interacting with the neurotransmitter, GABA, and modulating the activity of the neurotransmitter receptor, GABA receptors.

Potential Therapeutic Applications

The regulation of airway representation neurons (ARNS) by ZFAND2B provides new insights into the potential therapeutic applications of this protein. By targeting

Protein Name: Zinc Finger AN1-type Containing 2B

Functions: Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333)

The "ZFAND2B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZFAND2B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets