Target Name: MIX23
NCBI ID: G131076
Review Report on MIX23 Target / Biomarker Content of Review Report on MIX23 Target / Biomarker
MIX23
Other Name(s): mitochondrial matrix import factor 23 | Mitochondrial matrix import factor 23, transcript variant 1 | CCDC58 | MIX23 variant 1 | Protein MIX23 | coiled-coil domain-containing protein 58 | MIX23_HUMAN | Coiled-coil domain-containing protein 58 | Protein MIX23 (isoform 1) | coiled-coil domain containing 58

MIX23: A Mitochondrial Protein with Potential Therapeutic Applications

MIX23, also known as Mitochondrial Matrix Import Factor 23, is a protein that plays a crucial role in the regulation of mitochondrial dynamics and metabolism. MIX23 is a key player in the import of foreign proteins into the mitochondria, which is essential for the proper functioning of the organ.

MIX23 is a 21-kDa protein that is expressed in various tissues, including muscle, heart, brain, and kidney. It is primarily localized to the mitochondria, where it functions in the import of proteins involved in energy metabolism, such as NAD+-dependent sex hormone biosynthesis, myoglobin synthesis, and the detoxification of xenobiotics.

MIX23 functions as a scaffold protein, which helps to regulate the movement of mitochondrial proteins into the cytoplasm. It does this by interacting with the cytoplasmic protein TOM20, which is involved in the import of mitochondrial proteins.

In addition to its role in protein import, MIX23 is also involved in the regulation of mitochondrial dynamics and metabolism. It plays a key role in the assembly and disassembly of mitochondrial mitochondrial fusion proteins, which are responsible for regulating mitochondrial size and dynamics.

MIX23 is also involved in the regulation of mitochondrial ATP synthase, which is a critical enzyme involved in the production of ATP energy. MIX23 has been shown to play a role in the regulation of ATP synthase activity in various tissues, including muscle and heart.

MIX23 is a promising drug target and has been shown to have a neuroprotective effect in various models of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Studies have shown that MIX23 levels are decreased in the brains of individuals with Alzheimer's disease, and that inhibition of MIX23 has been shown to protect against neurodegeneration in these individuals.

In addition to its potential therapeutic applications, MIX23 is also a valuable biomarker for the diagnosis and monitoring of various neurodegenerative diseases. The levels of MIX23 have been shown to be decreased in the brains of individuals with Alzheimer's disease, and MIX23 has been shown to be a potential therapeutic target for this disease.

In conclusion, MIX23 is a protein that plays a crucial role in the regulation of mitochondrial dynamics and metabolism. Its functions as a scaffold protein and its involvement in the regulation of protein import, mitochondrial dynamics, and ATP synthase make it a promising drug target and a valuable biomarker for the diagnosis and monitoring of various neurodegenerative diseases. Further research is needed to fully understand the role of MIX23 in these processes and to develop effective therapies based on this protein.

Protein Name: Mitochondrial Matrix Import Factor 23

The "MIX23 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MIX23 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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