Understanding CYP3A7: A Potential Drug Target and Metabolite (G1551)

Target Name: CYP3A7

NCBI ID: G1551

CYP3A7

Understanding CYP3A7: A Potential Drug Target and Metabolite

CYP3A7, also known as CYP3A, is a cytochrome P450 enzyme that is primarily located in the liver and other organs. It is responsible for metabolizing a wide variety of drugs, including many statins, antidepressants, and benzodiazepines. Because of its role in drug metabolism With a key role, it is considered a potential target for many drug treatments and may also be an important indicator for evaluating drug efficacy and monitoring adverse drug reactions.

The genotypes of CYP3A7 are CYP3A4 and CYP3A6, which account for approximately 5-10% of the total human genome. It plays an important role in the body. It is the main CYP3A enzyme in the liver and is also expressed in other tissues in the body. The active center of CYP3A7 is located on the benzimidazole ring and has 5 伪-helices and 1 尾-sheet. Its function in organisms is achieved through redox reactions on the benzimidazole ring.

The metabolic pathway of CYP3A7 is very complex as it is involved in the metabolism of multiple drugs. In the liver, CYP3A7 together with other enzymes form the cytochrome P450 system, which is one of the most important metabolic pathways in the body. CYP3A7 metabolizes the substrate by binding to the substrate, forming an enzyme-substrate complex, and undergoing a redox reaction. These reactions include different chemical reactions such as hydrogenation, oxidation, reduction and dehydrogenation. Metabolites of CYP3A7 are pharmacologically active compounds that can alter the efficacy and pharmacokinetics of drugs.

As an important enzyme, CYP3A7 plays an important role in drug metabolism. The metabolism of many drugs depends on CYP3A7, so the activity of CYP3A7 has become an important indicator for measuring drug efficacy and monitoring adverse drug reactions. For example, CYP3A7 activity can be used to evaluate the efficacy of aspirin and many other NSAIDs because they can affect CYP3A7 activity. At the same time, the activity of CYP3A7 can also be used to predict the metabolic kinetics of other drugs and guide the formulation of drug dosage and dosage regimens.

In addition, CYP3A7 is also related to the metabolism of many drugs, including many antidepressants, anti-anxiety drugs, sedative-hypnotics, and hypnotics. The active center of CYP3A7 is highly conserved, making it a potential target for many drugs. Metabolites of CYP3A7 also have pharmacological activity and can affect the efficacy and pharmacokinetics of drugs. Therefore, studying the metabolic mechanism and drug interactions of CYP3A7 is of great significance for the design and optimization of drugs.

As an important enzyme, CYP3A7 plays an important role in drug metabolism. The activity of CYP3A7 has become an important indicator for measuring drug efficacy and monitoring adverse drug reactions. By studying the metabolic mechanism and drug interactions of CYP3A7, drug design and treatment options can be better understood and optimized to provide patients with better therapeutic effects.

Protein Name: Cytochrome P450 Family 3 Subfamily A Member 7

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•   protein structure and compound binding;
•   protein biological mechanisms;
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•   expression level;
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•   related combination drugs;
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