DNA-Directed RNA Polymerase (nonspecified subtype) Related Diseases

DNA-Directed RNA Polymerase (nonspecified subtype)

Related Diseases

1) Arthritis
Arthritis, also known as inflammatory joint disease, is related to rheumatoid arthritis and juvenile rheumatoid arthritis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Arthritis is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Entecavir and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and bone marrow, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and homeostasis/metabolism

2) Metabolic Diseases
3-Hydroxyacyl-Coa Dehydrogenase Deficiency, also known as hadh deficiency, is related to long-chain 3-hydroxyacyl-coa dehydrogenase deficiency and hyperinsulinemic hypoglycemia, familial, 4, and has symptoms including emaciation An important gene associated with 3-Hydroxyacyl-Coa Dehydrogenase Deficiency is HADH (Hydroxyacyl-CoA Dehydrogenase). The drugs Naloxone and Buprenorphine have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and skeletal muscle, and related phenotypes are feeding difficulties in infancy and growth delay

3) Gestational Trophoblastic Disease
Gestational Trophoblastic Neoplasm, also known as hydatidiform mole, is related to partial hydatidiform mole and placental site trophoblastic tumor. An important gene associated with Gestational Trophoblastic Neoplasm is NLRP7 (NLR Family Pyrin Domain Containing 7), and among its related pathways/superpathways are Peptide hormone metabolism and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Amifostine and Nitroglycerin have been mentioned in the context of this disorder. Affiliated tissues include placenta, lung and t cells, and related phenotypes are endocrine/exocrine gland and reproductive system

4) Sarcoma, Ewing
Ewing Sarcoma, also known as neuroepithelioma, is related to extraosseous ewing sarcoma and ewing sarcoma of bone, and has symptoms including eye manifestations, pain in or around eye and redness or discharge of eye. An important gene associated with Ewing Sarcoma is EWSR1 (EWS RNA Binding Protein 1), and among its related pathways/superpathways is Chromatin Regulation / Acetylation. The drugs Cobalt and Dactinomycin have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and bone marrow, and related phenotypes are peripheral primitive neuroectodermal neoplasm and nausea and vomiting

5) Acute Myeloid Leukemia
Acute Myeloblastic Leukemia with Maturation, also known as acute myeloblastic leukemia type 2, is related to myeloid leukemia and myeloid sarcoma. An important gene associated with Acute Myeloblastic Leukemia with Maturation is MIR181A1HG (MIR181A1 Host Gene), and among its related pathways/superpathways are Ras signaling and Hematopoietic Stem Cells and Lineage-specific Markers. The drugs Nicotine and Amsacrine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and t cells, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

6) Shwachman-Bodian-Diamond Syndrome
Shwachman-Diamond Syndrome 1, also known as shwachman-diamond syndrome, is related to exocrine pancreatic insufficiency and severe congenital neutropenia 8. An important gene associated with Shwachman-Diamond Syndrome 1 is SBDS (SBDS Ribosome Maturation Factor), and among its related pathways/superpathways are Metabolism of proteins and Viral mRNA Translation. The drugs Lenograstim and Vidarabine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and pancreas, and related phenotypes are exocrine pancreatic insufficiency and failure to thrive

7) Rhabdomyosarcoma
Rhabdomyosarcoma is related to embryonal rhabdomyosarcoma and rhabdomyosarcoma 2. An important gene associated with Rhabdomyosarcoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Disease and Prolactin Signaling. The drugs Morphine and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, lymph node and t cells, and related phenotypes are homeostasis/metabolism and neoplasm

8) Pain
Paine Syndrome, also known as pain disorder, is related to paroxysmal extreme pain disorder and indifference to pain, congenital, autosomal recessive. An important gene associated with Paine Syndrome is HFE (Homeostatic Iron Regulator), and among its related pathways/superpathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Pregabalin and Dinoprostone have been mentioned in the context of this disorder. Affiliated tissues include dorsal root ganglion, spinal cord and breast, and related phenotypes are microcephaly and spastic diplegia

9) Cancer, Breast
Breast Cancer, also known as breast carcinoma, is related to ovarian cancer and hereditary breast ovarian cancer syndrome, and has symptoms including pelvic pain, lameness, animal and pain. An important gene associated with Breast Cancer is BRCA2 (BRCA2 DNA Repair Associated), and among its related pathways/superpathways are Gene expression (Transcription) and ERK Signaling. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and prostate, and related phenotypes are breast carcinoma and Decreased viability

10) Cancer, Prostate
Prostate Cancer, also known as prostate carcinoma, is related to breast cancer and prostate disease, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Prostate Cancer is CHEK2 (Checkpoint Kinase 2), and among its related pathways/superpathways are Endometrial cancer and Breast cancer pathway. The drugs Sodium citrate and Sildenafil have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and lymph node, and related phenotypes are prostate cancer and neoplasm

11) Avian Influenza
Avian Influenza, also known as influenza in birds, is related to influenza and newcastle disease, and has symptoms including fever, cough and sore throat. An important gene associated with Avian Influenza is FURIN (Furin, Paired Basic Amino Acid Cleaving Enzyme), and among its related pathways/superpathways are Innate Immune System and Disease. The drugs Lactitol and Formaldehyde have been mentioned in the context of this disorder. Affiliated tissues include eye, kidney and heart, and related phenotypes are fatigue and fever

12) Graft-versus-host Disease
Graft-Versus-Host Disease, also known as graft-versus-host disease, susceptibility to, is related to bronchiolitis obliterans and acute graft versus host disease. An important gene associated with Graft-Versus-Host Disease is IL10 (Interleukin 10), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Tacrolimus and Lomustine have been mentioned in the context of this disorder. Affiliated tissues include Bone, bone marrow and t cells, and related phenotypes are elevated hepatic transaminase and skin erosion

13) Liver Diseases
Liver Disease, also known as liver diseases, is related to non-alcoholic fatty liver disease and fatty liver disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Liver Disease is MEG3 (Maternally Expressed 3), and among its related pathways/superpathways are Metabolism and Nuclear receptors meta-pathway. The drugs Perindopril and Amlodipine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and kidney, and related phenotypes are Reduced mammosphere formation and liver/biliary system

14) Hemoglobinopathies
Hemoglobinopathy, also known as hemoglobinopathies, is related to methemoglobinemia, beta-globin type and heinz body anemias, and has symptoms including cyanosis An important gene associated with Hemoglobinopathy is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and HIF-1-alpha transcription factor network. The drugs Ribavirin and Peginterferon alfa-2b have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, t cells and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

15) Yellow Fever
Yellow Fever, also known as urban yellow fever, is related to zika fever and west nile virus. An important gene associated with Yellow Fever is EIF2AK4 (Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Orange and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and skin, and related phenotypes are fever and increased circulating igm level

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