Arthritis
About the Disease
Arthritis, also known as inflammatory joint disease, is related to rheumatoid arthritis and juvenile rheumatoid arthritis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Arthritis is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Entecavir and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and bone marrow, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and homeostasis/metabolism
Common Targets
G3107 | Phosphodiesterase (nonspecified subtype) | G2931 | G959 | G3162 | G7422 | G1232 | G3821 | G4312 | G5320 | G102 | Interleukin-1 receptor-associated kinase (IRAK) (nonspecified subtype) | G4325 | G51284 | CDK4/Cyclin D3 | G6916 | G2220 | G8986 | G114548 | G8317 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | G3425 | G624 | G3604 | G3684 | G3718 | G22933 | G5294 | G121504 | G643 | G3716 | G1071 | G11255 | G132 | G6401 | G6647 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | G7403 | G3119 | G11200 | P2X2/3 Receptor Complex | G4353 | G5144 | G948 | C-C chemokine receptor (nonspecified subtype) | Lysophospholipid (edg) Receptors (nonspecified subtype) | G29851 | Prostaglandin EP Receptor (nonspecified subtype) | G50616 | G596 | G6696 | G840 | G6714 | G2209 | G51185 | G6097 | G6416 | G151306 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | G774 | G5599 | G3572 | G3576 | G3791 | G944 | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | Prostanoid Receptor (nonspecified subtype) | G781 | G11240 | P36692 | G81793 | cAMP Phosphodiesterase (nonspecified subtype) | Chemokine CXC receptor (nonspecified subtype) | G6622 | G54899 | Cyclin B (nonspecified subtype) | CDK4/Cyclin D1 | G9170 | G9415 | Calcium/calmodulin-dependent protein kinase (nonspecified subtype) | G6336 | P5760 | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | G6790 | G6870 | G23569 | G2936 | Calpain (nonspecified subtype) | G2350 | G51311 | G10892 | P16092 | G493856 | G9536 | Carbonic Anhydrase (nonspecified subtype) | G6865 | G4157 | G1956 | G51513 | Serum/glucocorticoid regulated kinase (Sgk) (nonspecified subtype) | Interleukin 17 (nonspecified subtype) | G25 | G3553 | G3717 | G5550 | G716 | G2150 | G7133 | G2191 | G3738 | G9088 | G923 | G9255 | G3984 | G5609 | G2915 | G1119 | DNA-Directed RNA Polymerase (nonspecified subtype) | G120892 | G1235 | Serine/Threonine Kinase (nonspecified subtype) | P18508 | G4615 | Tyrosine-Protein Kinases Src (nonspecified subtype) | G6774 | G3557 | G100137047 | G8722 | Tachykinin Receptor (nonspecified subtype) | G4149 | G84876 | P16704 | P5684 | Interleukin-1 (nonspecified subtype) | G2693 | G4543 | G10800 | G5733 | Phosphodiesterase 1 (PDE1) (nonspecified subtype) | G241 | G1445 | G407010 | G4986 | G5142 | G1017 | Endothelin-Converting Enzymes (ECE) (nonspecified subtype) | G3569 | G6402 | G191 | G4842 | G5029 | G56848 | Cyclin-dependent kinase (nonspecified subtype) | G3551 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | G3620 | G7015 | G4306 | G2217 | G5321 | G10013 | G283208 | G5739 | P5859 | G652 | G1646 | G52 | G1675 | CDK5/p25 | P5755 | G7376 | G406987 | G51177 | G3066 | G11009 | Acid-Sensing Ion Channel (ASIC) (nonspecified subtype) | Inhibitor of Apoptosis Proteins (IAPs) (nonspecified subtype) | G6328 | Phospholipase A2 (nonspecified subtype) | G695 | G3985 | G7431 | G3091 | Heat shock protein 90 (nonspecified subtype) | C-X-C Chemokine Receptor CXCR1/CXCR2 (IL-8 Receptor) (nonspecified subtype) | G56940 | G2053 | G727 | G23765 | G3163 | G1269 | G1520 | P6463 | G6778 | Chymotrypsin (nonspecified subtype) | G1/S-specific cyclin-E (nonspecified subtype) | G595 | Alpha-2 Adrenergic receptors (nonspecified subtype) | G1991 | G759 | G5578 | Folate Receptor (nonspecified subtype) | G11213 | G3371 | Mucin (nonspecified subtype) | P16577 | G771 | G5600 | Steroid 5-alpha-Reductase (nonspecified subtype) | Somatostatin receptor (nonspecified subtype) | G10280 | G11096 | G3274 | G4314 | G207 | G1236 | IL-1 Receptor (nonspecified subtype) | Casein kinase I (nonspecified subtype) | G1233 | G1432 | G1636 | G1021 | ADP-Ribosyl Cyclase/cyclic ADP-Ribose Hydrolase (ADPRC) (nonspecified subtype) | P5761 | G1514 | Matrix Metalloproteinase (MMP) (nonspecified subtype) | G10062 | G1111 | G6272 | G9212 | G146433 | Calcium channel (nonspecified subtype) | G7432 | G5465 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | G3932 | G558 | G116085 | Actin related protein 2/3 complex | Phospholipase C (nonspecified subtype) | G660 | Ribonucleoside-diphosphate reductase | G2357 | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | G3795 | G7099 | G10266 | Lipoxygenase (nonspecified subtype) | P6058 | G7297 | G1179 | Protein kinase C (nonspecified subtype) | G7299 | G887 | G6046 | AMP Deaminase (nonspecified subtype) | G1950 | G5024 | Integrin Receptor (nonspecified subtype) | G598 | G4321 | G8784 | G4128 | G415116 | G2152 | G846 | G8913 | G350 | G134 | G1436 | G8698 | Dimethylargininase (nonspecified subtype) | G649 | G80216 | G10846 | G6868 | G1020 | G3067 | G1723 | G7295 | G5152 | G2828 | G9020 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | Calcium-Activated K(Ca) Potassium Channel (nonspecified subtype) | P8262 | G4780 | G79054 | G8600 | G942 | G2022 | G2100 | G10320 | G3156 | G114609 | G3577 | G3357 | Phosphatidylinositol 4-Kinase beta (PI4K-beta) (nonspecified subtype) | G7150 | G3106 | G144811 | G7913 | G5291 | G1019 | G1312 | G1511 | Oxysterols receptor LXR (nonspecified subtype) | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | G2618 | G9097 | Opioid receptor (nonspecified subtype) | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | G4689 | CDK9/Cyclin T1 | G3815 | Adenylate Cyclase (nonspecified subtype) | G3350 | G51266 | G51377 | P12578 | G4921 | G3383 | G7412 | G7852 | G23411 | P33249 | G2253 | G5604 | Guanylate cyclase (nonspecified subtype) | G1268 | Raf kinase (nonspecified subtype) | G170482 | G19 | G1018 | P16176 | G775 | G2739 | G387597 | G7272 | G22943 | G3123 | G1139 | G23476 | G23576 | G8856 | P5561 | G590 | Adenosine deaminase (nonspecified subtype) | P6320 | G7433 | G5241 | G1490 | G5293 | G3689 | Estrogen receptor (nonspecified subtype) | G7052 | G51393 | P5762 | G51523 | G100 | G6610 | G1859 | G729230 | Inhibitory kappaB Kinase (IKK) (nonspecified subtype) | G719 | G79718 | G6403 | P5867 | DNA Topoisomerase II (nonspecified subtype) | G837 | G8841 | G5595 | G960 | P11113 | G673 | G7075 | G7535 | Histone acetyltransferase (HAT) (nonspecified subtype) | P5756 | G5091 | G1025 | G958 | G3290 | G5467 | G952 | G4159 | G7514 | G51135 | P5833 | G80739 | G2990 | G3122 | Na+/K+-ATPase (nonspecified subtype) | CDK4/Cyclin D | G3702 | G1803 | G22914 | G9261 | CDK6/Cyclin D1 | G142 | G200576 | G231 | G5601 | G1066 | G135 | G581 | G6773 | G6850 | 15-Lipoxygenase (nonspecified subtype) | G3615 | G7442 | G6095 | G3605 | P5662 | G5034 | G5580 | STAT5 (nonspecified subtype) | G3741 | G5159 | G5340 | G1120 | Tyrosine Kinase (nonspecified subtype) | P16126 | G7046 | G4889 | G3554 | G6754 | G4316 | G7498 | Cysteine Protease (nonspecified subtype) | G11156 | Phospholipase A2, Cytosolic (nonspecified subtype) | G4170 | G3065 | G5742 | G5770 | G23621 | G5468 | G904 | G140 | P40594 | G7225 | G43 | G4985 | G5729 | G706 | G208 | G51094 | G2833 | G841 | G920 | G3567 | G2101 | G4609 | G10886 | Heme Oxygenase (HO) (nonspecified subtype) | G4914 | Interferon (nonspecified subtype) | G11251 | Cyclin D (nonspecified subtype) | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | G6885 | G2932 | sigma Receptor (nonspecified subtype) | Trypsin (nonspecified subtype) | G5066 | G53831 | G23308 | G57007 | G3663 | G3990 | G823 | G3105 | Retinoid acid receptor (nonspecified subtype) | G554213 | G1812 | G4860 | G5734 | G1147 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | G6646 | G931 | G9429 | P15736 | G6441 | G586 | P16964 | CDK1/Cyclin B | Peptidylprolyl Isomerase (nonspecified subtype) | G2475 | G54795 | Elastase (nonspecified subtype) | G3630 | G412 | G5153 | G2538 | G8792 | G10203 | G9971 | G162514 | G1075 | G5147 | G10563 | G1491 | Aggrecanase (nonspecified subtype) | G2166 | G1230 | P5753 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | G896 | G9759 | G2690 | G6256 | Leukotriene B4 receptor (LTB4-R) (nonspecified subtype) | Serine protease (nonspecified subtype) | G6775 | G4322 | Tryptase (nonspecified subtype) | G3832 | G1437 | G1378 | Caspase (nonspecified subtype) | Transforming growth factor beta (nonspecified subtype) | G4017 | G2099 | G941 | Sodium channel (nonspecified subtype) | G5315 | G2862 | G23028 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | G23135 | G5138 | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | G9507 | G623 | Mitogen-Activated Protein Kinase (nonspecified subtype) | G4210 | G53637 | G2358 | G836 | G100528032 | G6096 | L-Type calcium channel (nonspecified subtype) | G6789 | G4318 | G2194 | G51752 | CDK2/Cyclin A | Heat shock protein 70 (nonspecified subtype) | G2321 | G2697 | G64499 | G6529 | G84171 | G5300 | G27346 | G10188 | G898 | G2908 | P11025 | G5894 | P5757 | Adenosine receptor (nonspecified subtype) | Poly [ADP-ribose] polymerase (nonspecified subtype) | Janus Kinase (nonspecified subtype) | G5579 | G3552 | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 (nonspecified protein) | G7010 | Protein Tyrosine Phosphatase Type IVA (nonspecified subtype) | G26191 | G5602 | G3099 | Glutaminase (nonspecified subtype) | G196 | G22953 | G335 | G5745 | G4846 | G760 | G3394 | G125893 | P34548 | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | G1513 | G5292 | G2212 | G768 | G780 | G5045 | G6335 | G6523 | G4481 | G4602 | G8843 | G5141 | G9966 | G3558 | Cyclooxygenase (COX) (nonspecified subtype) | G41 | G7941 | Gastric H+/K+-ATPase | G1889 | G8019 | G26279 | G5328 | G1301 | Chemokine receptor (nonspecified subtype) | G4317 | G2104 | G728 | G59067 | P13475 | G154 | G2160 | G7293 | G3269 | Hypoxia-Inducible Factor Prolyl Hydroxylase (nonspecified subtype) | G3579 | alpha1-Adrenoceptor (nonspecified subtype) | G6869 | G777 | G2548 | G84695 | G301 | G5648 | G10988 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | Phospholipase A2, Secretory (sPLA2) (nonspecified subtype) | Sphingolipid delta(4)-desaturase (nonspecified subtype) | P5758 | G50508 | G5588 | G4142 | G8654 | CDK2/Cyclin E | G3991 | G50604 | P6348 | G10855 | P5754 | Angiotensin receptor (AT) (nonspecified subtype) | G4160 | CDK6/Cyclin D3 | G834 | Glutathione S-Transferase (GST) (nonspecified subtype) | Endothelin receptor (nonspecified subtype) | Histamine Receptor (HR) (nonspecified subtype) | G1508 | P34550 | G3818 | G718 | G4313 | G84254 | Cyclin-dependent kinase inhibitor (nonspecified subtype) | G1786 | G5605 | Histone H2A (nonspecified subtype) | G185 | G5046 | G3146 | G177 | G406938 | P6884 | Nitric oxide synthase (NOS) (nonspecified subtype) | G338442 | Calcium/calmodulin-dependent protein kinase type II (CaMK-II) | G2155 | G54106 | G11082 | G5743 | P5678 | G7421 | Cyclin A (nonspecified subtype) | G355 | G4843 | G5423 | G5027 | alpha-Amylase (nonspecified subtype) | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | G7298 | G839 | G3458 | CDK3/Cyclin E | Retinoid RXR receptor (nonspecified subtype) | G7874 | G2625 | G11167 | G3356 | G123099 | G3654 | G367 | G4233 | G23173 | G11103 | Collagenase (nonspecified subtype) | G3358 | G761 | G8560 | G940 | G1493 | G8989 | G4282 | G710 | G4323 | G4319 | G213 | G1234 | P24924 | G5290 | G10000 | G2064 | G2896 | G29843 | G7132 | G4363 | G64115 | G3956 | G290 | G5581 | G1141 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | Potassium Channels (nonspecified subtype) | G8737 | Bradykinin receptor (nonspecified subtype) | Dual Specificity Mitogen-Activated Protein Kinase Kinase (MEK) (nonspecified subtype) | G2534 | 11beta-Hydroxysteroid Dehydrogenase (nonspecified subtype) | G4048 | G1901 | G8974 | TLR4/MD-2 complex | IL-17 Receptor (nonspecified subtype) | Melanocortin receptor (nonspecified subtype) | P16740 | G54567 | G7124 | G23643 | G64781 | G1719 | G3570 | G240 | G5150 | G2740 | Glutathione peroxidase (nonspecified subtype) | G3586 | G4129 | G5156 | G8639 | G10495 | P11049 | G1509 | G5724 | G3565 | G2322 | G9388 | G9718 | G1215 | G2247 | G5979 | P5767 | G2034 | G5266 | Epoxide Hydrolase (nonspecified subtype) | G3635 | G387 | G5732 | G7351 | G50615 | G3293 | P13024 | G7153 | G8767 | G1380 | Histone deacetylase (nonspecified subtype) | G676 | G2161 | G2993 | G126014 | NADPH Oxidase (nonspecified subtype) | G169355 | G983 | G152 | G1588 | G9290 | Superoxide dismutase (SOD) (nonspecified subtype) | G3596 | G149233 | G246 | G5243 | G11040 | G3606 | G2642
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• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
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• related combination drugs;
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