alpha-Mannosidase (nonspecified subtype) Related Diseases

alpha-Mannosidase (nonspecified subtype)

Related Diseases

1) Alpha-mannosidosis
Mannosidosis, Alpha B, Lysosomal, also known as alpha-mannosidosis, is related to mannosidosis, beta a, lysosomal and angiokeratoma, and has symptoms including muscle spasticity and gait ataxia. An important gene associated with Mannosidosis, Alpha B, Lysosomal is MAN2B1 (Mannosidase Alpha Class 2B Member 1), and among its related pathways/superpathways are Metabolism and Diseases of glycosylation. The drugs Sorbitol and Glycine have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and tongue, and related phenotypes are intellectual disability and macroglossia

2) Limb Girdle Muscular Dystrophy
Limb-Girdle Muscular Dystrophy, also known as lgmd, is related to muscular dystrophy, limb-girdle, autosomal recessive 1 and muscular dystrophy, limb-girdle, autosomal dominant 3. An important gene associated with Limb-Girdle Muscular Dystrophy is CAPN3 (Calpain 3), and among its related pathways/superpathways are Cardiac conduction and DREAM Repression and Dynorphin Expression. The drugs (3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium and Lisinopril have been mentioned in the context of this disorder. Affiliated tissues include heart, skeletal muscle and smooth muscle, and related phenotypes are no effect and no effect

3) Sezary Syndrome
Sezary's Disease, also known as sezary syndrome, is related to primary cutaneous t-cell non-hodgkin lymphoma and lymphoma, hodgkin, classic, and has symptoms including pruritus An important gene associated with Sezary's Disease is BCL10 (BCL10 Immune Signaling Adaptor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Denileukin diftitox and Fosaprepitant have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and bone marrow, and related phenotypes are dry skin and neoplasm of the skin

4) Glioblastoma Multiforme
Glioblastoma, also known as glioblastoma multiforme, is related to brain cancer and glioma, and has symptoms including headache and seizures. An important gene associated with Glioblastoma is MIR21 (MicroRNA 21), and among its related pathways/superpathways is miRNAs involved in DNA damage response. The drugs Trametinib and Dabrafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and eye, and related phenotypes are glioblastoma multiforme and abnormal cell morphology

5) Gaucher Disease
Gaucher's Disease, also known as gaucher disease, is related to gaucher disease, type ii and gaucher disease, type iii, and has symptoms including apnea, muscle rigidity and muscle spasticity. An important gene associated with Gaucher's Disease is GBA1 (Glucosylceramidase Beta 1), and among its related pathways/superpathways are Metabolism and Sphingolipid metabolism. The drugs Sofosbuvir and Ledipasvir have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and bone marrow, and related phenotypes are splenomegaly and hepatomegaly

6) Diabetes
Diabetes Mellitus, also known as diabetes, is related to type 2 diabetes mellitus and gestational diabetes, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Diabetes Mellitus is KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11), and among its related pathways/superpathways are Regulation of beta-cell development and Cell differentiation - expanded index. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone marrow and kidney.

7) Tuberculosis
Mycobacterium Tuberculosis 1, also known as tuberculosis, is related to pulmonary tuberculosis and miliary tuberculosis, and has symptoms including coughing, fever and pruritus. An important gene associated with Mycobacterium Tuberculosis 1 is MTBS1 (Mycobacterium Tuberculosis, Susceptibility To Infection By, 1), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Calcium carbonate and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include lungs, lymph nodes and pericardium, and related phenotypes are fatigue and fever

8) Liver Diseases
Liver Disease, also known as liver diseases, is related to non-alcoholic fatty liver disease and fatty liver disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Liver Disease is MEG3 (Maternally Expressed 3), and among its related pathways/superpathways are Metabolism and Nuclear receptors meta-pathway. The drugs Perindopril and Amlodipine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and kidney, and related phenotypes are Reduced mammosphere formation and liver/biliary system

9) Obesity
Body Mass Index Quantitative Trait Locus 11, also known as obesity, is related to leptin deficiency or dysfunction and type 2 diabetes mellitus, and has symptoms including high weight, symptoms and obesity, metabolically benign. An important gene associated with Body Mass Index Quantitative Trait Locus 11 is UCP3 (Uncoupling Protein 3), and among its related pathways/superpathways are Beta-2 adrenergic-dependent CFTR expression and Glucose / Energy Metabolism. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, liver and heart, and related phenotypes are obesity and decreased resting energy expenditure

10) Hyperglycemia
Hyperglycemia is related to type 1 diabetes mellitus and maturity-onset diabetes of the young, type 2, and has symptoms including cachexia, cyanosis and dyspnea. An important gene associated with Hyperglycemia is MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1), and among its related pathways/superpathways are Metabolism and Nervous system development. The drugs Saxagliptin and Aripiprazole have been mentioned in the context of this disorder. Affiliated tissues include endothelial, liver and brain, and related phenotypes are Decreased viability and Decreased viability

11) Melanoma
Melanoma, also known as malignant melanoma, is related to skin melanoma and melanoma, cutaneous malignant 1, and has symptoms including exanthema and pruritus. An important gene associated with Melanoma is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Vindesine and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and t cells, and related phenotypes are normal and pigmentation

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•   protein structure and compound binding;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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