TMPRSS11D: A Potential Drug Target and Biomarker (G9407)

Target Name: TMPRSS11D

NCBI ID: G9407

TMPRSS11D

TMPRSS11D: A Potential Drug Target and Biomarker

TMPRSS11D (Transmembrane serine protease 11D) is a protein that is expressed in various tissues throughout the body, including the brain, heart, kidneys, and intestines. It plays a crucial role in the regulation of cell signaling pathways, including the production of neurotransmitters, such as serotonin and dopamine.

Recent studies have identified TMPRSS11D as a potential drug target and biomarker for various psychiatric and neurological disorders, including depression, anxiety, and neurodegenerative diseases. This is because the levels of TMPRSS11D are often reduced in individuals with these conditions, and drugs that can increase the levels of TMPRSS11D have been shown to have therapeutic effects.

One of the key factors that makes TMPRSS11D an attractive drug target is its location in the brain. TMPRSS11D is primarily expressed in the postsynaptic neurons, which are the cells that receive neurotransmitters from the neurons and transmit them to other cells. This location makes it a potential target for drugs that can modulate neurotransmitter release and activity.

In addition, TMPRSS11D has been shown to be involved in the production of other proteins that are involved in neurotransmission, such as the neurotransmitter acetylcholine. This suggests that it may be a useful biomarker for assessing the effectiveness of drugs that target neurotransmitter systems.

Another potential aspect of TMPRSS11D as a drug target is its role in the regulation of pain signaling. TMPRSS11D has been shown to be involved in the production of other proteins that are involved in pain signaling, including the neurotransmitter nociceptide. This suggests that it may be a potential target for drugs that can inhibit pain signaling.

Finally, TMPRSS11D has also been shown to be involved in the regulation of synaptic plasticity, which is the ability of the brain to change and adapt over time. This suggests that it may be a potential target for drugs that can modulate synaptic plasticity, which could be useful for treating a variety of neurological disorders.

In conclusion, TMPRSS11D is a protein that has been shown to be involved in a variety of processes that are important for brain function. As a result, it is a potential drug target and biomarker for a variety of psychiatric and neurological disorders. Further research is needed to fully understand the role of TMPRSS11D in these conditions and to develop effective treatments.

Protein Name: Transmembrane Serine Protease 11D

Functions: May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate

The "TMPRSS11D Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMPRSS11D comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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