TMPRSS11BNL: A Potential Drug Target and Biomarker (G401136)

Target Name: TMPRSS11BNL

NCBI ID: G401136

TMPRSS11BNL

Other Name(s): TMPRSS11B N-terminal like, pseudogene

TMPRSS11BNL: A Potential Drug Target and Biomarker

TMPRSS11B is a nuclear protein that is expressed in various tissues and cell types, including the brain, heart, and pancreas. It is a member of the Toll-like receptor (TLR) family 11, which is involved in the innate immune response. TMPRSS11BNL is the N-terminal like pseudogene of the TMPRSS11 gene, which is located on chromosome 19.

The TMPRSS11 gene is encoding a protein that is similar to the N-terminal region of the TLR1 gene, which is located on chromosome 6. TLR1 is a key gene that is involved in the innate immune response, and it is expressed in a variety of cell types, including immune cells, epithelial cells, and neural cells. The N-terminal region of TLR1 is thought to be involved in the formation of the N-terminal domain of the protein, which is involved in interactions with intracellular signaling molecules.

TMPRSS11BNL is a 24.1 kb protein that is expressed in the brain, heart, and pancreas, and it is highly conserved at the amino acid level. It has a molecular weight of 21.1 kDa and a calculated pI of 6.8. TMPRSS11BNL is a monomer and has a single transmembrane domain. It has been shown to interact with several intracellular signaling molecules, including NF-kappa-B, MAPK, and PI3K.

In addition to its potential role in the innate immune response, TMPRSS11BNL is also thought to be involved in several other cellular processes, including cell signaling, cell adhesion, and neurotransmission. For example, TMPRSS11BNL has been shown to be involved in the regulation of neurotransmitter release from axonally projecting neurons, and it has been shown to interact with several neurotransmitter receptors, including dopamine, GABA, and glutamate.

As a potential drug target, TMPRSS11BNL is an attractive target for drug development due to its unique mechanism of action and its involvement in several important cellular processes. TMPRSS11BNL is a good candidate for small molecule inhibitors, as it has a relatively small molecule interface and a well-characterized protein structure. Additionally, its role in the innate immune response and its interaction with several intracellular signaling molecules make it an attractive target for drugs that target signaling pathways involved in inflammation, stress, and neurodegeneration.

In conclusion, TMPRSS11BNL is a potential drug target and biomarker that has been shown to be involved in several important cellular processes. Its unique mechanism of action and its well-characterized protein structure make it an attractive target for small molecule inhibitors. Further research is needed to fully understand the role of TMPRSS11BNL in cellular processes and to develop effective drugs that target its unique mechanism of action.

Protein Name: TMPRSS11B N-terminal Like, Pseudogene

The "TMPRSS11BNL Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMPRSS11BNL comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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