TMEM87A: A Transmembrane Protein Identified as a Potential Drug Target and Biomarker

Target Name: TMEM87A

NCBI ID: G25963

TMEM87A

TMEM87A: A Transmembrane Protein Identified as a Potential Drug Target and Biomarker

TMEM87A, also known as Transmembrane protein 87A, is a gene encoding a protein located at the cell membrane that plays a crucial role in various physiological processes. The primary function of TMEM87A is to regulate the movement of positively charged ions, such as potassium and sodium, into and out of the cells. It does this by forming a transmembrane pore, allowing these ions to pass through the membrane and regulate the concentration gradient.

TMEM87A has been identified as a potential drug target and biomarker due to its unique structure and the involvement of several diseases, including epilepsy and heart disease. In this article, we will explore the molecular mechanisms underlying TMEM87A's function, its potential as a drug target, and its potential as a biomarker for several diseases.

Molecular Mechanisms

TMEM87A is a member of the superfamily of transmembrane proteins, which are involved in the regulation of various physiological processes, including ion and water transport. These proteins typically have a transmembrane domain that is responsible for creating a pore allowing molecules to pass through the membrane. TMEM87A is characterized by a long N-terminal cytoplasmic domain, a transmembrane domain, and a C-terminal cytoplasmic domain.

The TMEM87A protein has a unique structure that allows it to interact with various molecules, including small molecules, ions, and even entire cells. The cytoplasmic domain of TMEM87A contains several putative transmembrane interactions (TMIs), which are regions of the protein that are involved in the formation of the pore. These interactions can form a strong interaction between TMEM87A and small molecules, leading to the regulation of ion and water transport.

TMEM87A has also been shown to interact with ions, such as potassium and sodium, which are essential for various physiological processes, including muscle and nerve function. The cytoplasmic domain of TMEM87A contains several potential binding sites for these ions, which allows it to regulate their movement into and out of the cells.

In addition to its interactions with ions, TMEM87A has also been shown to interact with entire cells, such as heart cells and neurons. This interaction may play a role in the regulation of various physiological processes, including cell growth, apoptosis, and neurodegeneration.

Potential Drug Target

TMEM87A's unique structure and its interactions with various molecules make it an attractive target for drug development. Studies have shown that blocking TMEM87A can lead to the inhibition of ion and water transport, as well as the regulation of cell growth and apoptosis. This suggests that TMEM87A may be a useful drug target for various physiological processes, including epilepsy and heart disease.

In addition to its potential use as a drug target, TMEM87A has also been identified as a potential biomarker for several diseases. The regulation of ion and water transport is involved in various physiological processes, including the regulation of muscle and nerve function, which are often affected in diseases such as epilepsy and heart disease.

TMEM87A has also been shown to be involved in the regulation of cell growth and apoptosis, which are involved in the development and progression of various diseases, including cancer. The inhibition of TMEM87A's function may have implications for the treatment of these diseases.

Biomarker Potential

TMEM87A has been shown to be involved in the regulation of various physiological processes, including cell growth, apoptosis, and neurodegeneration. This suggests that it may be a useful biomarker for the diagnosis and

Protein Name: Transmembrane Protein 87A

Functions: May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN)

The "TMEM87A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM87A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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