Target Name: NQO1
NCBI ID: G1728
Review Report on NQO1 Target / Biomarker Content of Review Report on NQO1 Target / Biomarker
NQO1
Other Name(s): DHQU | Azoreductase | phylloquinone reductase | Dioxin-inducible 1 | NAD(P)H quinone dehydrogenase 1, transcript variant 1 | azoreductase | DT-diaphorase | NMORI | Quinone reductase 1 | menadione reductase | NMOR1 | NAD(P)H dehydrogenase [quinone] 1 (isoform a) | NAD(P)H:Quinone acceptor oxidoreductase type 1 | QR1 | NAD(P)H:quinone oxidoreductase 1 | NAD(P)H dehydrogenase [quinone] 1 | NAD(P)H dehydrogenase [quinone] 1 (isoform c) | NQO1 variant 3 | NAD(P)H quinone dehydrogenase 1, transcript variant 2 | NAD(P)H dehydrogenase, quinone 1 | diaphorase-4 | NAD(P)H:(quinone-acceptor) oxidoreductase | NAD(P)H:menadione oxidoreductase 1 | quinone reductase 1 | Diaphorase (NADH/NADPH) (cytochrome b-5 reductase) | Phylloquinone reductase | Menadione reductase | DIA4 | NAD(P)H menadione oxidoreductase 1, dioxin-inducible | NAD(P)H:quinone oxireductase | NQO1_HUMAN | DTD | NAD(P)H quinone dehydrogenase 1 | NQO1 variant 1 | Diaphorase-4 | NAD(P)H quinone dehydrogenase 1, transcript variant 3 | NQO1 variant 2 | diaphorase (NADH/NADPH) (cytochrome b-5 reductase) | dioxin-inducible 1 | NAD(P)H dehydrogenase [quinone] 1 (isoform b)

NQO1: A Drug Target / Disease Biomarker

NQO1 (N-acetyl-L-cysteine), also known as NACCS or N-acetyl-L-cysteine hydroxylase, is a protein that is expressed in various tissues and cells throughout the body. It is a key enzyme in the cysteine catabolism pathway, which is the final step in the production of proteins from amino acids. NQO1 is responsible for breaking down the amino acid cysteine and releasing the amino acid cysteine, which is then used to synthesize other proteins.

NQO1 is a potential drug target for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its role in the cysteine catabolism pathway has also led to its potential as a biomarker for certain diseases.

One of the key reasons why NQO1 is a promising drug target is its involvement in the production of proteins that are involved in many different diseases. For example, NQO1 has been shown to be involved in the production of proteins that are involved in cancer, including proteins that promote tumor growth and the development of cancer cells. Additionally, NQO1 has been shown to be involved in the production of proteins that are involved in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

Another reason why NQO1 is a promising drug target is its role in the cysteine catabolism pathway. This pathway is involved in the production of proteins from amino acids, and NQO1 is responsible for breaking down the amino acid cysteine and releasing the amino acid cysteine. This process is important for the production of other proteins, including proteins that are involved in many different physiological processes in the body. However, the production of these other proteins is often disrupted in diseases such as cancer and neurodegenerative diseases, which may contribute to the development and progression of these diseases.

In addition to its role in the cysteine catabolism pathway, NQO1 is also a potential biomarker for several diseases. For example, NQO1 has been shown to be involved in the production of proteins that are involved in cancer, including proteins that promote tumor growth and the development of cancer cells. Additionally, NQO1 has been shown to be involved in the production of proteins that are involved in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. These findings suggest that NQO1 may be a useful biomarker for the diagnosis and treatment of these diseases.

Overall, NQO1 is a protein that is involved in several important processes in the body, including the production of proteins from amino acids and the cysteine catabolism pathway. Its potential as a drug target and biomarker makes it an attractive target for research into the treatment of various diseases.

Protein Name: NAD(P)H Quinone Dehydrogenase 1

Functions: Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (PubMed:8999809, PubMed:9271353) (By similarity). Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (PubMed:8999809, PubMed:9271353, PubMed:15102952). Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (PubMed:8999809). Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (PubMed:15687255, PubMed:28291250)

The "NQO1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NQO1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

NQO2 | NR0B1 | NR0B2 | NR1D1 | NR1D2 | NR1H2 | NR1H3 | NR1H4 | NR1I2 | NR1I3 | NR2C1 | NR2C2 | NR2C2AP | NR2E1 | NR2E3 | NR2F1 | NR2F1-AS1 | NR2F2 | NR2F2-AS1 | NR2F6 | NR3C1 | NR3C2 | NR4A1 | NR4A2 | NR4A3 | NR5A1 | NR5A2 | NR6A1 | NRAD1 | NRADDP | NRAP | NRARP | NRAS | NRAV | NRBF2 | NRBF2P4 | NRBP1 | NRBP2 | NRCAM | NRDC | NRDE2 | NREP | NRF1 | NRG1 | NRG2 | NRG3 | NRG4 | NRGN | NRIP1 | NRIP2 | NRIP3 | NRIP3-DT | NRIR | NRK | NRL | NRM | NRN1 | NRN1L | NRON | NRP1 | NRP2 | NRROS | NRSN1 | NRSN2 | NRSN2-AS1 | NRTN | NRXN1 | NRXN2 | NRXN2-AS1 | NRXN3 | NSA2 | NSA2P2 | NSD1 | NSD2 | NSD3 | NSDHL | NSF | NSFL1C | NSFP1 | NSG1 | NSG2 | NSL complex | NSL1 | NSMAF | NSMCE1 | NSMCE1-DT | NSMCE2 | NSMCE3 | NSMCE4A | NSMF | NSRP1 | NSUN2 | NSUN3 | NSUN4 | NSUN5 | NSUN5P1 | NSUN5P2 | NSUN6 | NSUN7 | NT5C