NQO2: A Potential Drug Target and Biomarker for Xenobiotics (G4835)
NQO2: A Potential Drug Target and Biomarker for Xenobiotics
Quinone Reductase 2 (NQO2) is a protein that is expressed in various cell types throughout the body. NQO2 plays a crucial role in the detoxification of xenobiotics, which are harmful substances that can cause oxidative stress and damage to cells. NQO2 is a key enzyme in the xenobiotic response pathway, which is a critical system that helps the body to eliminate xenobiotics from its cells.
Recent studies have identified NQO2 as a potential drug target for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. The NQO2 enzyme has also been identified as a potential biomarker for these diseases, as the levels of NQO2 in cells can be affected by the presence of xenobiotics.
One of the key reasons for the potential drug targeting of NQO2 is its role in the detoxification of xenobiotics. Many xenobiotics, such as polycyclic aromatic hydrocarbons (PAHs) and heterofulvins, can cause oxidative stress and damage to cells. NQO2 is the enzyme that is responsible for detoxifying these xenobiotics, which helps to protect the cell from damage.
In addition to its role in the detoxification of xenobiotics, NQO2 is also involved in the regulation of cellular processes that are important for cell survival. For example, NQO2 is involved in the production of reactive oxygen species (ROS), which can cause damage to cells if they are not properly regulated. Additionally, NQO2 is involved in the production of superoxide, a toxic oxidant that can cause inflammation and contribute to a variety of diseases.
The potential drug targeting of NQO2 is due to its ability to interact with a variety of drug targets. For example, NQO2 has been shown to interact with the drug targets that are involved in cell survival and metabolism. This has led to the idea that NQO2 may be a useful drug target for diseases that are caused by the inhibition of these drug targets.
In addition to its potential drug targeting, NQO2 is also a potential biomarker for a variety of diseases. The levels of NQO2 in cells can be affected by the presence of xenobiotics, which can indicate the presence of these drugs in the body. This has led to the idea that NQO2 may be a useful biomarker for diseases that are caused by the exposure to xenobiotics.
Overall, NQO2 is a protein that is involved in the detoxification of xenobiotics and the regulation of cellular processes. The potential drug targeting of NQO2 is due to its ability to interact with a variety of drug targets and its potential as a biomarker for diseases. Further research is needed to fully understand the role of NQO2 in the body and its potential as a drug and biomarker.
Protein Name: N-ribosyldihydronicotinamide:quinone Reductase 2
Functions: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis
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• general information;
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• the target screening and validation;
• expression level;
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• drug resistance;
• related combination drugs;
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