Target Name: GTF2IP4
NCBI ID: G100093631
Review Report on GTF2IP4 Target / Biomarker Content of Review Report on GTF2IP4 Target / Biomarker
Other Name(s): general transcription factor IIi pseudogene 4 | General transcription factor IIi pseudogene 4 | GTF2I

Diving into GTF2IP4: Exploring a Potential Drug Target and Biomarker


In the field of drug discovery and development, identifying effective drug targets and biomarkers is crucial. These molecules serve as important cues, helping scientists design therapeutic strategies or assess disease progression. One such promising candidate is GTF2IP4, a protein that has gained significant attention for its potential as both a drug target and biomarker. In this article, we will delve into the various aspects of GTF2IP4 and its implications in the world of medicine.

What is GTF2IP4?

GTF2IP4, also known as general transcription factor II-I-interacting protein 4, is a protein encoded by the GTF2IP4 gene. It is primarily found in the nucleus of cells and is involved in the transcriptional regulation of gene expression. GTF2IP4 functions by interacting with the general transcription factor II-I (GTF2I), which is responsible for initiating gene transcription.

The Role of GTF2IP4 as a Drug Target:

GTF2IP4 has emerged as a potential drug target due to its involvement in various disease processes. Several studies have highlighted its role in cancer, neurodegenerative diseases, and cardiovascular disorders. By targeting GTF2IP4, researchers aim to modulate gene expression and subsequently inhibit abnormal cellular functions associated with these diseases.

In cancer, GTF2IP4 has been found to play a crucial role in tumor growth and metastasis. Studies have shown that its expression levels are elevated in various cancer types, including breast, lung, and colon cancer. By targeting GTF2IP4, researchers hope to inhibit tumor progression and metastasis, ultimately improving patient outcomes.

GTF2IP4 has also been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's. Aberrant gene expression has been observed in these diseases, leading to the accumulation of toxic protein aggregates. Recent studies suggest that targeting GTF2IP4 may help correct the dysregulated gene expression, potentially slowing down disease progression and providing a novel therapeutic avenue.

Moreover, GTF2IP4 has been linked to cardiovascular disorders, including atherosclerosis and heart failure. The protein is involved in the regulation of genes associated with inflammation and vascular remodeling. By targeting GTF2IP4, researchers aim to reduce inflammation and prevent the development of atherosclerotic plaques, thereby reducing the risk of cardiovascular events.

GTF2IP4 as a Biomarker:

In addition to its potential as a drug target, GTF2IP4 also shows promise as a biomarker. Biomarkers are measurable indicators that provide insights into the presence, severity, or progression of a particular disease. GTF2IP4, with its distinct expression patterns across different diseases, could serve as a valuable biomarker for diagnostic or prognostic purposes.

In cancer, GTF2IP4 expression levels have been correlated with tumor stage, grade, and patient survival. High expression of GTF2IP4 has been associated with a more aggressive tumor phenotype and poorer prognosis. As a biomarker, GTF2IP4 could be used to identify patients who are at higher risk or require more intensive treatment, guiding clinicians in making informed decisions.

Similarly, GTF2IP4 expression has shown promise in neurodegenerative diseases. Researchers have observed alterations in GTF2IP4 expression in the brains of individuals with Alzheimer's and Parkinson's, indicating its potential as a diagnostic biomarker. Detecting deviations in GTF2IP4 levels could aid in early disease detection and monitoring disease progression over time.

Challenges and Future Directions:

While the potential of GTF2IP4 as both a drug target and biomarker is promising, several challenges lie ahead. One major hurdle is the development of specific and effective therapeutic agents that can modulate GTF2IP4 activity without causing detrimental side effects. Additionally, further research is needed to validate GTF2IP4 as a reliable biomarker across different diseases and populations.

In conclusion, GTF2IP4 holds immense potential as both a drug target and biomarker in various diseases. Understanding its role in disease pathogenesis and harnessing its therapeutic and diagnostic capabilities could revolutionize the way we approach healthcare. With ongoing research and advancement, GTF2IP4 may become an essential player in the fight against cancer, neurodegenerative diseases, and cardiovascular disorders.

Protein Name: General Transcription Factor IIi Pseudogene 4

The "GTF2IP4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GTF2IP4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at

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