GTPBP1: A Potential Drug Target and Biomarker (G9567)

Target Name: GTPBP1

NCBI ID: G9567

GTPBP1

GTPBP1: A Potential Drug Target and Biomarker

Guanosine triphosphate (GTP) is a crucial molecule in cell signaling pathways. It plays a vital role in intracellular signaling, and its levels have been linked to various diseases, including cancer, neurodegenerative disorders, and developmental defects. The G-protein 1 (GTPBP1 ) gene is a key regulator of GTP levels and has been implicated in several cellular processes. As a result, GTPBP1 has emerged as a promising drug target and biomarker for a variety of diseases.

GTPBP1 functions as a negative regulator of the protein kinase A (PKA), which is an essential enzyme involved in many cellular processes, including cell signaling, DNA replication, and metabolism. The activity of PKA is regulated by GTP, which activates the protein to act as a catalyst for phosphorylation, which modifies the activity of the protein and affects its stability.

GTPBP1 is a 21-kDa protein that consists of a catalytic alpha-helices and a transmembrane beta-sheet. Its catalytic alpha-helices contain three parallel beta-strands that give the protein its unique structure and function. GTPBP1 has been shown to have a A highly conserved sequence, with a calculated entropy of only 11.9 kcal/mol, which suggests that it has a relatively stable structure.

GTPBP1 is highly expressed in many tissues, including brain, heart, and muscle. It is also expressed in various cell types, including cancer cells, and has been shown to be involved in various cellular processes, including cell signaling, cell division, and tissue repair.

One of the most significant functions of GTPBP1 is its role in regulating the activity of PKA. GTPBP1 has been shown to interact with PKA and prevent its activation. This interaction between GTPBP1 and PKA provides a negative feedback mechanism that helps maintain the stability of cellular signaling pathways.

In addition to its role in regulating PKA, GTPBP1 has also been shown to be involved in various signaling pathways. For example, GTPBP1 has been shown to be involved in the regulation of the DNA damage response (DDR), a critical pathway that helps repair damaged DNA in response to environmental stressors, such as radiation and chemicals.

GTPBP1 has also been shown to play a role in the regulation of cell growth and metabolism. For example, GTPBP1 has been shown to inhibit the activity of the oncogene transforming growth factor (TGF-2), which is involved in the regulation of cell growth , and has been shown to promote the degradation of TGF-2-induced breast cancer cells.

In conclusion, GTPBP1 is a protein that has a significant impact on cellular signaling pathways. Its role in regulating PKA and various other signaling pathways makes it a promising drug target and biomarker for a variety of diseases. Further research is needed to fully understand the functions of GTPBP1 and its potential as a drug.

Protein Name: GTP Binding Protein 1

Functions: Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity)

The "GTPBP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GTPBP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets