Identification of Potential EZH1 Inhibitors (G2145)

Target Name: EZH1

NCBI ID: G2145

EZH1

Identification of Potential EZH1 Inhibitors

Histone-lysine N-methyltransferase EZH1 (EZH1) is a gene that has been well-studied for its role in the regulation of gene expression and DNA replication. EZH1 is a member of the SCAV3 family of enzymes that belong to the DNA polymerase I (DNA-PM) superfamily. EZH1 functions by modifying the histone proteins, which are the proteins that make up the nucleosome, the basic unit of DNA.

The histone proteins play a critical role in the regulation of gene expression. They can interact with various transcription factors to either activate or repress gene transcription. EZH1 is well-known for its role in the regulation of the gene expression of the tumor suppressor gene, p53. EZH1 has been shown to play a role in the regulation of p53-mediated gene repression by modifying the histone H3 lysine 27 trimer.

In addition to its role in the regulation of p53-mediated gene repression, EZH1 is also involved in the regulation of cell growth and differentiation. It has been shown to play a role in the regulation of cell cycle progression, and is involved in the regulation of the G1/S transition.

EZH1 is also involved in the regulation of DNA replication. It has been shown to play a role in the regulation of DNA replication by modifying the histone proteins, which are involved in the initiation of DNA replication.

EZH1 is a potential drug target for various diseases, including cancer. Its role in the regulation of gene expression and DNA replication makes it an attractive target for small molecules that can inhibit its function.

One of the most promising strategies for targeting EZH1 is the use of small molecules that can modulate its activity. One class of small molecules that have been shown to be effective in inhibiting EZH1 function is the DNA-binding small molecules that can modulate the activity of DNA-PM enzymes. These small molecules include inhibitors of DNA-PM enzymes such as inhibitors of the enzyme responsible for the repair of DNA damage, NAD+-dependent DNA-PM enzyme inhibitors, and small molecules that can modulate the activity of the enzyme involved in the regulation of DNA replication, such as the enzyme responsible for the initiation of DNA replication, DNA polymerase I.

Another class of small molecules that have been shown to be effective in inhibiting EZH1 function are the small molecules that can modulate the activity of the SCAV3 enzyme. These small molecules include inhibitors of the enzyme responsible for the synthesis of the histone proteins, and inhibitors of the enzyme involved in the regulation of DNA replication.

In conclusion, EZH1 is a gene that plays a critical role in the regulation of gene expression and DNA replication. Its function as a histone-lysine N-methyltransferase makes it an attractive target for small molecules that can inhibit its activity. Further research is needed to identify small molecules that can effectively inhibit EZH1 function and their potential therapeutic applications.

Protein Name: Enhancer Of Zeste 1 Polycomb Repressive Complex 2 Subunit

Functions: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation

The "EZH1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about EZH1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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