TMEM100: A Protein with Unique Structure and Subcellular Localization That Could Be A Drug Target Or Biomarker

Target Name: TMEM100

NCBI ID: G55273

TMEM100

Other Name(s): TM100_HUMAN | Transmembrane protein 100, transcript variant 1 | TMEM100 variant 1 | Transmembrane protein 100 | transmembrane protein 100

TMEM100: A Protein with Unique Structure and Subcellular Localization That Could Be A Drug Target Or Biomarker

TMEM100 (Tissue Membrane Extender 100), also known as TM100_HUMAN, is a protein that is expressed in various tissues throughout the body. It is a member of the superfamily of transmembrane proteins, which are a type of protein that spans the cell membrane and can interact with various intracellular and extracellular molecules. TMEM100 is of particular interest as a potential drug target or biomarker due to its unique structure and subcellular localization.

TMEM100 is a 21-kDa protein that is expressed in a variety of tissues, including muscle, heart, liver, kidney, and brain. It is primarily localized to the endoplasmic reticulum (ER) and endosomal system, which are specialized structures that are involved in the delivery and processing of proteins to the cell surface. TMEM100 is also expressed in the plasma membrane (PM) and cytosol, which are the cell's outer and intracellular environments, respectively.

TMEM100's unique structure is one of its most striking features. It is a type of transmembrane protein that consists of a single transmembrane domain and a cytoplasmic tail. The transmembrane domain is responsible for the protein's unique ability to interact with various intracellular and extracellular molecules, while the cytoplasmic tail is responsible for helping the protein to navigate the endosomal system and the plasma membrane.

TMEM100's subcellular localization is another feature that makes it an interesting candidate for a drug target or biomarker. Because it is primarily localized to the ER and endosomal system, these structures are under constant scrutiny by the cell and are often targeted by various enzymes and diseases. As a result, TMEM100 is a prime candidate for intervention strategies aimed at modifying the cell's endoplasmic and endosomal systems.

In addition to its unique structure and subcellular localization, TMEM100 is also of interest as a potential drug target due to its role in various cellular processes. For example, TMEM100 has been shown to be involved in the regulation of cell adhesion, which is a critical process that helps to maintain the integrity of tissues and organs. Additionally, TMEM100 has been shown to be involved in the regulation of cell survival and apoptosis, which are critical processes that help to maintain the homeostasis of cells.

TMEM100's potential as a drug target or biomarker is further enhanced by its expression in a variety of tissues, which suggests that it may be a useful target for interventions aimed at modifying cellular processes in a variety of diseases. For example, TMEM100 has been shown to be involved in a variety of diseases, including neurodegenerative disorders, cancer, and cardiovascular disease.

In conclusion, TMEM100 is a protein that is expressed in various tissues throughout the body and has unique structure and subcellular localization. Its involvement in various cellular processes makes it an interesting candidate for intervention strategies aimed at modifying endoplasmic and endosomal systems. Additionally, TMEM100's expression in a variety of tissues makes it a potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of TMEM100 in cellular processes and its potential as a drug target or biomarker.

Protein Name: Transmembrane Protein 100

Functions: Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex

The "TMEM100 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM100 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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