TMEM101: A Potential Drug Target and Biomarker for Membrane Transport-Related Disorders

Target Name: TMEM101

NCBI ID: G84336

TMEM101

TMEM101: A Potential Drug Target and Biomarker for Membrane Transport-Related Disorders

Introduction

Membrane transport-related disorders have a significant impact on human health, affecting millions of individuals worldwide. These disorders result from the impaired transport of various molecules across the membrane, leading to their accumulation in the cell or the tissue, and potentially leading to pathological changes . Some of the most common membrane transport-related disorders include congenital and acquired diseases, such as CHARACTERISTIC CHEMISTRY AND TRANSPORT (CHCT) disorders, which result from defects in the transport proteins.

One of the most well-known transport proteins is Transmembrane protein 101 (TMEM101), also known as Kinesin-67 (K6.7) or Kinesin-like protein (KLF1). TMEM101 is a member of the Kinesin family, which includes several other proteins involved in the transport of various molecules across cell membranes. TMEM101 plays a crucial role in the transport of a variety of molecules, including small molecules, ions, and proteins across the cell membrane, and its dysfunction has been implicated in a number of membrane transport-related disorders.

TMEM101 Localization and Functions

TMEM101 is a transmembrane protein that is located at the end of the cytoskeleton and is involved in the regulation of the cytoskeleton-associated protein (CAP) complex. The CAP complex is a network of proteins that help maintain the cytoskeleton in a stable and organized state , and is involved in a variety of cellular processes, including cell division, cytoskeletal organization, and cell signaling. TMEM101 is one of the key components of the CAP complex, and its localization to the end of the cytoskeleton suggests that it plays a critical role in regulating the movement and organization of the CAP complex.

In addition to its role in the CAP complex, TMEM101 has also been shown to play a role in the regulation of the transport of various molecules across the cell membrane. For example, TMEM101 has been shown to transport small molecules, such as glucose and amino acids, across the cell membrane, and its dysfunction in this process has been linked to a variety of membrane transport-related disorders, including the neurodegenerative disorder, Alzheimer's disease.

TMEM101 Interactions with Other Membrane Transport Proteins

TMEM101 is not present in isolation, and its functions are highly dependent on the interactions with other proteins. TMEM101 plays a critical role in the regulation of the activity of the CAP complex, as well as several other transport proteins that are involved in the transport of various molecules across the cell membrane. For example, TMEM101 has been shown to interact with the protein known as p110, which is a G protein-coupled receptor (GPCR) that is involved in the regulation of a variety of cellular processes, including cell signaling and the regulation of ion channels. The interaction between TMEM101 and p110 suggests that TMEM101 may play a role in the regulation of the activity of p110, and may be a potential drug target for the treatment of membrane transport-related disorders.

TMEM101 as a Potential Drug Target

The potential use of TMEM101 as a drug target is high due to its involvement in the regulation of various membrane transport-related disorders. Its functions in the regulation of the CAP complex and the transport of small molecules suggest that TMEM101 may be a useful target for the treatment of a variety of disorders that are characterized by the impaired regulation of membrane transport proteins.

TMEM101 has also been shown to play a role in

Protein Name: Transmembrane Protein 101

Functions: May activate NF-kappa-B signaling pathways

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