TMEFF2: A Transmembrane Protein with EGF-Like and Follistatin-Like Domains, Potential Drug Target or Biomarker

Target Name: TMEFF2

NCBI ID: G23671

TMEFF2

TMEFF2: A Transmembrane Protein with EGF-Like and Follistatin-Like Domains, Potential Drug Target or Biomarker

TMEFF2, which stands for Transmembrane protein with EGF-like and two Follistatin-like domains, is a protein that has been identified in various scientific studies as having potential drug target or biomarker properties. EGF-like domains are known for their ability to promote cell growth, while follistatin-like domains have been shown to play a role in regulating cell growth and differentiation. The discovery of this protein has significant implications for the development of new therapeutic approaches for various diseases.

Structure and Function

TMEFF2 is a transmembrane protein that is expressed in various tissues, including the brain, heart, and liver. It consists of 158 amino acids and has a calculated molecular mass of 17.1 kDa. The protein has a characteristic EGF-like domain at its amino-terminal side, as well as two follistatin-like domains, located at its C-terminus.

The EGF-like domain is a key region that is known to possess multiple growth-promoting properties. This domain is typically found in proteins that are involved in cell signaling pathways, including the TGF-β pathway. TMEFF2 has been shown to activate the TGF-β pathway, which is involved in cell growth, differentiation, and repair. This suggests that TMEFF2 may have a role in promoting cell growth and may be a potential drug target.

The follistatin-like domains are a unique feature that are found in only a few proteins. These domains are known for their ability to regulate cell growth and have been shown to play a role in the regulation of various cellular processes, including cell cycle progression, apoptosis, and angiogenesis. The presence of follistatin-like domains in TMEFF2 suggests that this protein may have a role in regulating cell growth and may be a potential biomarker for certain diseases.

Expression and Localization

TMEFF2 is expressed in various tissues and cells, including the brain, heart, and liver. It has been shown to be expressed in the primary neuron in the brain, indicating a potential role in neurodegenerative diseases. Additionally, TMEFF2 has been shown to be expressed in heart muscle cells, suggesting a potential role in the regulation of heart function.

TMEFF2 is also expressed in the liver, which is a key organ for the detoxification of various substances in the body. The liver plays a critical role in the regulation of the levels of various toxins and drugs, making it an attractive target for the development of new therapeutic approaches.

Drug Target Potential

TMEFF2's EGF-like domain has been shown to promote cell growth, which suggests that it may be a potential drug target for diseases that involve cellular growth. One such disease is cancer. Cancer is a disease that involves the uncontrolled growth and proliferation of cells, leading to the development of tumors. TMEFF2's ability to promote cell growth may make it an attractive target for the development of new anti-cancer therapeutic approaches.

Another potential drug target for TMEFF2 is neurodegenerative diseases, such as Alzheimer's disease. TMEFF2 has been shown to be expressed in the primary neuron in the brain, which is the site of the majority of neurodegenerative diseases. The regulation of cellular processes by TMEFF2 may be involved in the development and progression of these diseases.

Biomarker Potential

TMEFF2's follistatin-like domains have been shown to play a role in the regulation of cell growth and apoptosis. This suggests that it may be a potential biomarker for diseases that are characterized by uncontrolled cell growth or the failure of cellular processes. One such disease is cancer. The regulation

Protein Name: Transmembrane Protein With EGF Like And Two Follistatin Like Domains 2

Functions: May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation

The "TMEFF2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEFF2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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