CYP3A5: A Multi-Functional Gene in Drug Metabolism and Genetics

Target Name: CYP3A5

NCBI ID: G1577

CYP3A5

CYP3A5: A Multi-Functional Gene in Drug Metabolism and Genetics

CYP3A5 (Cytochrome P450 family 3 subfamily A member 5, transcript variant 1) is a gene that encodes a protein known as CYP3A5. CYP3A5 is a member of the cytochrome P450 family, which is a large gene family that plays a crucial role in the metabolism of various drugs and other substances in the body.

CYP3A5 is a gene that has been implicated in the metabolism of many drugs, including statins, benzodiazepines, and anticancer agents. It is also a potential drug target for many diseases, including cancer, cardiovascular disease, and neurodegenerative disorders.

One of the key functions of CYP3A5 is its role in metabolizing drugs. Many drugs work by binding to receptors on the surface of cells, and CYP3A5 is responsible for breaking down those drugs so that they can be eliminated from the body. This is an important function because if drugs are not properly metabolized, they can build up in the body and cause harm.

CYP3A5 is also involved in the metabolism of other substances in the body, including some toxins and environmental pollutants. This means that CYP3A5 may be a useful biomarker for tracking the effectiveness of certain treatments and for identifying potential risks associated with drug use.

In addition to its role in drug metabolism, CYP3A5 is also known for its role in gene regulation. The CYP3A5 gene has been shown to play a role in regulating the expression of other genes, including genes involved in cell signaling and inflammation. This suggests that CYP3A5 may be a useful target for drugs that are designed to modulate gene expression.

CYP3A5 is also a potential drug target for cancer. Many studies have suggested that CYP3A5 may be involved in the development and progression of certain types of cancer, including breast, ovarian, and prostate cancers. For example, some studies have shown that inhibitors of CYP3A5 have been effective in treating certain types of cancer.

In addition to its potential as a drug target and biomarker, CYP3A5 is also of interest to researchers because of its location on the genetic map. The cytochrome P450 gene family is one of the most widely studied gene families in the human genome, and many researchers are interested in understanding how the expression of CYP3A5 and other genes is regulated in different contexts.

Overall, CYP3A5 is a gene that has important roles in drug metabolism and gene regulation, and it is of interest as a potential drug target and biomarker for many diseases. Further research is needed to fully understand the functions of CYP3A5 and its potential as a therapeutic target.

Protein Name: Cytochrome P450 Family 3 Subfamily A Member 5

Functions: A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins (PubMed:2732228, PubMed:10681376, PubMed:11093772, PubMed:12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:12865317, PubMed:2732228, PubMed:10681376, PubMed:11093772). Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione (PubMed:2732228). Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporine (PubMed:2732228)

The "CYP3A5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CYP3A5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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