Calcium Homeostasis Modulator Family Member 4: A Promising Drug Target and Potential Biomarker

Target Name: CALHM4

NCBI ID: G221301

CALHM4

Calcium Homeostasis Modulator Family Member 4: A Promising Drug Target and Potential Biomarker

Abstract:
Calcium homeostasis modulator family member 4 (CALHM4) is a transmembrane protein that plays a crucial role in regulating calcium homeostasis, which is a critical regulatory process that controls various physiological functions in the body. CalHM4 is a G protein-coupled receptor (GPCR), which means it interacts with intracellular signaling molecules to regulate calcium ions (Ca2+) levels. In this article, we will discuss the CalHM4 protein, its function, potential drug targets, and potential use as a biomarker.

Introduction:
Ca2+ is a vital signaling molecule that plays a critical role in various physiological processes, including muscle contractions, nerve function, and cell signaling. It is essential for the proper functioning of many cellular processes, including intracellular signaling, and is often regulated to maintain a balance within the body. However, when the levels of calcium ions in the body become too high or too low, problems can arise. For example, an imbalance of calcium ions can cause muscle spasms, tremors, and other neurological disorders. Additionally, high levels of calcium ions can also contribute to the development of certain diseases, such as heart disease and Alzheimer's disease.

CalHM4: A protein that regulates calcium homeostasis:
The CalHM4 protein is a member of the calcium homeostasis modulator family, which includes several other proteins that regulate calcium ions in the body. These proteins work by interacting with intracellular signaling molecules, such as GPCRs, to regulate the levels of calcium ions in the body. CalHM4 is a GPCR that is expressed in many different tissues and cells throughout the body, including the brain, heart, and kidneys.

The function of CalHM4:
CalHM4 is involved in the regulation of many physiological processes that involve the balance of calcium ions in the body. For example, it is involved in the regulation of muscle contractions and the contraction of blood vessels. It is also involved in the regulation of the release of certain ions from the brain, such as glutamate and GABA. Additionally, CalHM4 is involved in the regulation of the balance of calcium ions in the body's cells, which is critical for maintaining the structure and function of these cells.

Potential drug targets:
CalHM4 is a potential drug target for several reasons. Firstly, it is a GPCR, which means that it interacts with intracellular signaling molecules. This makes it a good candidate for drugs that target GPCRs. Secondly, CalHM4 is involved in many physiological processes that are important for overall health, making it an attractive target for drugs that promote health and prevent disease.

Potential biomarkers:
CalHM4 is also a potential biomarker for several diseases. For example, high levels of CalHM4 have been associated with the development of certain neurological disorders, such as Alzheimer's disease and Parkinson's disease. Additionally, CalHM4 has been shown to be involved in the regulation of the balance of calcium ions in the brain, which is important for the development and progression of certain neurological disorders.

Conclusion:
In conclusion, the CalHM4 protein is a member of the calcium homeostasis modulator family that plays a crucial role in regulating the balance of calcium ions in the body. Its function as a GPCR makes it a potential drug target, and its potential as a biomarker for disease makes it an attractive target for research into the development of new treatments. Further research is needed to fully understand the role of CalHM4 in the regulation of calcium homeostasis and its potential as a drug target and biomarker.

Protein Name: Calcium Homeostasis Modulator Family Member 4

Functions: Pore-forming subunit of a voltage-gated ion channel

The "CALHM4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CALHM4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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