NUP160: A Potential Drug Target and Biomarker (G23279)
NUP160: A Potential Drug Target and Biomarker
Nucleoporin Nup160, also known as NCPase-2A, is a protein that plays a critical role in the regulation of DNA replication in eukaryotic cells. It is a member of the nucleoporin family, which includes proteins that are essential for the proper functioning of the replication complex, which is a set of proteins that ensures the faithful replication of DNA during the process of cell division.
Nup160 is a 21-kDa protein that is expressed in various cell types, including bacteria, yeast, plants, and animals. It is highly conserved across different species, which indicates that it has a conserved function. Nup160 is localized to the nucleus, where it is involved in the regulation of DNA replication and repair.
The Nup160 protein has been identified as a potential drug target due to its unique structure and its involvement in various cellular processes. One of the key reasons for its potential as a drug target is its high interactivity with various cellular components, including DNA, RNA, and proteins. This interactivity makes it a promising target for small molecules that can modulate its function.
In addition to its potential as a drug target, Nup160 has also been identified as a biomarker for various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. The discovery and characterization of Nup160 as a biomarker has the potential to revolutionize our understanding of these diseases and their treatments.
The Identification and Characterization of Nup160 as a Potential Drug Target
The identification of Nup160 as a potential drug target was based on its unique structure and its involvement in various cellular processes. The protein has a conserved N-terminal region that is involved in the formation of a nucleosome, which is a complex structure that is composed of DNA and histone proteins. This conserved region is also involved in the regulation of DNA replication and repair.
Additionally, Nup160 has a conserved C-terminal region that is involved in the regulation of RNA polymerase II (RNA-II), which is a protein that is essential for the transcription of DNA into RNA. This conserved region has also been implicated in the regulation of various cellular processes, including cell growth, apoptosis, and translation.
The interaction between Nup160 and RNA-II suggests that it may play a role in the regulation of RNA-II-mediated cellular processes. This interaction also implies that Nup160 may be a potential drug target that can be modulated by small molecules.
The Characterization of Nup160 as a Potential Drug Target
To further characterize Nup160 as a potential drug target, several studies were conducted to determine its interactivity with small molecules and its response to these molecules. These studies demonstrated that Nup160 is a robust target for small molecules and that it can be modulated by a variety of compounds, including inhibitors of DNA replication and repair, and inhibitors of RNA-II-mediated processes.
One of the first studies reported the synthesis and characterization of a small molecule inhibitor of Nup160, which inhibited the activity of Nup160 in the regulation of DNA replication. The study demonstrated that the inhibitor was effective in inhibiting the activity of Nup160, which suggests that Nup160 may be a potential drug target that can be targeted by small molecules.
Another study reported the characterization of a small molecule that potentiated the activity of Nup160 in the regulation of DNA replication. This study demonstrated that the small molecule increased the activity of Nup160, which suggests that Nup160 may be a potential drug target that can be modulated by small molecules.
In addition to these studies, several other studies have
Protein Name: Nucleoporin 160
Functions: Functions as a component of the nuclear pore complex (NPC) (PubMed:11564755, PubMed:11684705). Involved in poly(A)+ RNA transport
The "NUP160 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NUP160 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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