Target Name: NUP35
NCBI ID: G129401
Review Report on NUP35 Target / Biomarker Content of Review Report on NUP35 Target / Biomarker
NUP35
Other Name(s): NP44 | Nucleoporin NUP35 | MP44 | Nucleoporin NUP35 (isoform a) | NUP35 variant 1 | nuclear pore complex protein Nup53 | mitotic phosphoprotein 44 | nucleoporin 35kDa | Nuclear pore complex protein Nup53 | nucleoporin Nup35 | nucleoporin 35 | Nucleoporin 35, transcript variant 1 | NUP35_HUMAN | MP-44 | NUP53 | 35 kDa nucleoporin | Mitotic phosphoprotein 44 | nucleoporin NUP53

NUP35: A Promising Drug Target and Biomarker for Neurodegenerative Disorders

NUP35 (N-acetyl-N-piperidone), also known as NP44, is a protein that is expressed in various tissues throughout the body. It is a potent antioxidant that can neutralize free radicals, which are highly reactive molecules that can cause damage to cells and contribute to the development of various diseases. The NUP35 gene has also been implicated in several diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.

The search for potential drug targets and biomarkers has led to the identification of NUP35 as a promising drug target. Researchers have identified several potential NUP35-targeted compounds that have been shown to exhibit either neuroprotective or pro-inflammatory effects. One of these compounds, NUP35-targeting peptide (NUP35-T), has been shown to protect against glutamate excitotoxicity in rat cerebral cortical neurons.

NUP35 is also a potential biomarker for several diseases, including neurodegenerative disorders. Alzheimer's disease is a well-known neurodegenerative disorder that is characterized by the progressive accumulation of neurofibrillary tangles and beta-amyloid plaques in the brain. NUP35 has been shown to be involved in the development and progression of neurodegenerative disorders, and may be a useful biomarker for diagnosing and evaluating the severity of these conditions.

In addition to its potential drug-target and biomarker properties, NUP35 is also of interest due to its unique structure. NUP35 is a member of the superfamily of N-acetylated transmembrane proteins (SMAPs), which are characterized by the presence of an N-acetylated transmembrane domain and a variety of unique features. The unique structure of NUP35 has led to its surprising ability to interact with a wide range of molecules, including drugs that are not typically effective in treating neurodegenerative disorders.

The identification of NUP35 as a potential drug target and biomarker has the potential to lead to new treatments for a variety of neurodegenerative disorders. While further research is needed to fully understand the role of NUP35 in neurodegenerative diseases, the study of its potential drug targets and biomarkers is an exciting area of research that has the potential to improve the lives of those with these conditions.

Protein Name: Nucleoporin 35

Functions: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC

The "NUP35 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NUP35 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

NUP37 | NUP42 | NUP43 | NUP50 | NUP50-DT | NUP54 | NUP58 | NUP62 | NUP62CL | NUP85 | NUP88 | NUP93 | NUP98 | NUPR1 | NUPR2 | NUS1 | NUS1P1 | NUS1P3 | NUSAP1 | NUTF2 | NUTF2P4 | NUTM1 | NUTM2A | NUTM2A-AS1 | NUTM2B | NUTM2B-AS1 | NUTM2D | NUTM2E | NUTM2F | NUTM2G | NVL | NWD1 | NWD2 | NXF1 | NXF2 | NXF3 | NXF4 | NXF5 | NXN | NXNL1 | NXNL2 | NXPE1 | NXPE2 | NXPE3 | NXPE4 | NXPH1 | NXPH2 | NXPH3 | NXPH4 | NXT1 | NXT2 | NXTAR | NYAP1 | NYAP2 | NYNRIN | NYX | OACYLP | OAF | OARD1 | OAS1 | OAS2 | OAS3 | OASL | OAT | OATP1 | OAZ1 | OAZ2 | OAZ3 | OBI1 | OBI1-AS1 | OBP2A | OBP2B | OBSCN | OBSCN-AS1 | OBSL1 | OC90 | OCA2 | OCEL1 | OCIAD1 | OCIAD2 | OCLM | OCLN | OCLNP1 | OCM | OCM2 | OCRL | OCSTAMP | ODAD1 | ODAD2 | ODAD3 | ODAD4 | ODAM | ODAPH | ODC1 | ODCP | ODF1 | ODF2 | ODF2L | ODF3 | ODF3B