Study of ITGB3BP: Role in Cell-Cell Adhesion and Multiple Processes

Target Name: ITGB3BP

NCBI ID: G23421

ITGB3BP

Study of ITGB3BP: Role in Cell-Cell Adhesion and Multiple Processes

ITGB3BP (integrin beta-3-binding protein) is a protein that is expressed in many different tissues throughout the body, including the placenta, liver, and kidneys. It is a member of the integrin alpha-2 chain, which is a subunit of the protein integrin that is involved in cell-cell adhesion.

One of the functions of ITGB3BP is to interact with integrin alpha-2, which allows it to participate in the process of cell-cell adhesion. This is important for many different processes in the body, including the development and maintenance of tissues such as tissues, organs, and organs.

In addition to its role in cell-cell adhesion, ITGB3BP is also involved in the regulation of many different processes in the body. For example, it has been shown to be involved in the development and maintenance of blood vessels, and in the regulation of blood pressure.

Despite its widespread expression, little is known about ITGB3BP. There are currently no drugs that are specifically designed to target ITGB3BP, and research into its potential uses is in its early stages. However, its role in cell-cell adhesion and its involvement in the regulation of many different processes in the body make it an attractive target for future research.

In conclusion, ITGB3BP is a protein that is involved in many different processes in the body. While its role in cell-cell adhesion and its potential uses are still being explored, its potential as a drug target or biomarker make it an important molecule to study further.

Protein Name: Integrin Subunit Beta 3 Binding Protein

Functions: Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex

The "ITGB3BP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ITGB3BP comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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