ITSN1: A Potential Drug Target and Biomarker (G6453)

Target Name: ITSN1

NCBI ID: G6453

ITSN1

ITSN1: A Potential Drug Target and Biomarker

ITSN1 (Intersectin 1, transcript variant 1) is a protein that is expressed in various tissues throughout the body, including the nervous system, endothelial cells, and various immune cells. Its function is not well understood, but it is known to be involved in several cellular processes, including cell adhesion, migration, and invasion. In recent years, researchers have become interested in ITSN1 as a potential drug target or biomarker due to its unique structure and various functions.

Structure and Localization

The ITSN1 protein is a member of the intercellular adhesion molecule (ICAM) family, which includes several proteins that are involved in cell-cell adhesion. ITSN1 is a 21-kDa protein that consists of 106 amino acid residues. It has a unique structure that includes a long N-terminus that is involved in several interacting proteins, a middle transmembrane region that contains several ITER domains, and a C-terminus that is involved in several cytoplasmic interactions.

ITSN1 is expressed in various tissues throughout the body, including the brain, spinal cord, skin, heart, and blood vessels. It is also expressed in various cell types, including neurons, astrocytes, endothelial cells, and immune cells. ITSN1 is primarily localized to the cytoplasm of these cells, but it can also be found in the cell surface and in the extracellular matrix (ECM).

Function

ITSN1 is involved in several cellular processes, including cell adhesion, migration, and invasion. It is a key regulator of cell-cell adhesion and plays a role in the regulation of neuronal migration and the development of neurodegenerative diseases.

One of ITSN1's most well-known functions is its role in cell adhesion. ITSN1 is involved in the formation of tight junctions, which are a type of cell-cell adhesion that helps to maintain the integrity of tissues. tight junctions are critical for the proper functioning of various tissues, including the brain and the nervous system.

In addition to its role in cell adhesion, ITSN1 is also involved in the regulation of cell migration. It has been shown to play a role in the regulation of cell migration in various tissues, including the brain and the nervous system. This is important for the development and maintenance of tissues and organs, as well as for the proper functioning of the immune system.

ITSN1 has also been shown to be involved in the regulation of inflammation. It has been shown to play a role in the regulation of inflammation in various tissues, including the skin and the blood vessels. This is important for the proper functioning of the immune system and for the regulation of tissue repair.

Drug Targeting

Due to its unique structure and various functions, ITSN1 has become an attractive target for drug development. Researchers have shown that ITSN1 can be targeted with small molecules, antibodies, and other therapeutic agents.

One of the most promising strategies for targeting ITSN1 is the use of small molecules that can modulate its activity. Researchers have shown that various small molecules, including inhibitors of tyrosine kinase activity and inhibitors of the formation of tight junctions, can reduce the activity of ITSN1. These small molecules have been shown to be effective in animal models of various diseases, including neurodegenerative diseases and autoimmune diseases.

Another approach for targeting ITSN1 is the use of antibodies that can specifically recognize and interact with it. Researchers have shown that antibodies that recognize specific regions of ITSN1 have been effective in animal models of various diseases, including neurodegenerative diseases and autoimmune diseases. These antibodies have been shown to be effective in blocking the activity of ITSN1 and reducing the development of neurodegenerative diseases.

Conclusion

ITSN1 is a protein that is involved in several cellular processes throughout the body. Its unique structure and various functions have made it an attractive target for drug development. Researchers have shown that ITSN1 can be

Protein Name: Intersectin 1

Functions: Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688)

The "ITSN1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ITSN1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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