ITM2B (BRI2 intracellular domain): A Potential Drug Target and Biomarker for G protein-Coupled Receptors

Target Name: ITM2B

NCBI ID: G9445

ITM2B

ITM2B (BRI2 intracellular domain): A Potential Drug Target and Biomarker for G protein-Coupled Receptors

Introduction

G protein-coupled receptors (GPCRs) are a family of transmembrane proteins that play a crucial role in cellular signaling. They are involved in various physiological processes, including sensory perception, neurotransmission, and hormone signaling. GPCRs are mediated by intracellular signaling pathways, which involves the interaction between GPCRs, intracellular signaling pathways, and downstream signaling pathways. The ITM2B (BRI2 intracellular domain) protein is a potential drug target and biomarker for GPCRs due to its unique structure, function, and involvement in intracellular signaling pathways.

Structure and Function of ITM2B

The ITM2B protein is a 21-kDa protein that is localized to the endoplasmic reticulum (ER) and the nuclear envelope (NE). It is composed of a unique transmembrane region that consists of an N-terminal cytoplasmic domain, a transmembrane region, and an C-terminal intracellular domain. The intracellular domain is characterized by a long amino acid sequence that includes a unique farnesylated cysteine 鈥嬧?媟esidue, which is known as cysteine-516.

The ITM2B protein plays a critical role in intracellular signaling pathways, particularly in the regulation of cell signaling pathways, including the G-protein-coupled receptor (GPCR) signaling pathway. GPCRs are involved in various physiological processes, including sensory perception, neurotransmission, and hormone signaling. They are mediated by intracellular signaling pathways, which involve the interaction between GPCRs, intracellular signaling pathways, and downstream signaling pathways. The ITM2B protein is involved in the regulation of GPCR signaling pathway by interacting with the intracellular signaling pathway.

Expression and Localization of ITM2B

The ITM2B protein is expressed in various tissues and cells, including the brain, sensory neurons, and cancer cells. It is predominantly expressed in the brain, where it is involved in the regulation of neural signaling pathways. The ITM2B protein is also expressed in the endoplasmic reticulum (ER) and the nuclear envelope (NE), which suggests a potential role in intracellular signaling pathways.

The ITM2B protein is also involved in the regulation of protein-protein interactions (PPIs) and in the regulation of cellular signaling pathways. It interacts with various intracellular signaling pathway proteins, including the protein kinase B (PKB), the protein kinase A (PKA ), and the protein kinase C (PKC). These interactions are critical for the regulation of intracellular signaling pathways and the regulation of cellular signaling pathways.

Drug Targeting ITM2B

The ITM2B protein is a potential drug target due to its involvement in intracellular signaling pathways and its unique structure. The cysteine-516 residue, which is located in the intracellular domain of ITM2B, is a potential target for small molecules. Studies have shown that the cysteine-516 residue is involved in the regulation of protein-protein interactions (PPIs) and is a critical residue for the regulation of intracellular signaling pathways.

In addition to its involvement in intracellular signaling pathways, the ITM2B protein is also involved in the regulation of cellular signaling pathways. It interacts with various intracellular signaling pathway proteins, including the protein kinase B (PKB), the protein kinase A (PKA), and the protein kinase C (PKC). These interactions are critical for the regulation of intracellular signaling pathways and the regulation of cellular signaling pathways. Therefore, small molecules that can modulate the activity of these intracellular signaling pathway proteins may be useful

Protein Name: Integral Membrane Protein 2B

Functions: Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites

The "ITM2B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ITM2B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets