JPH4: A Non-Coding RNA Molecule as A Potential Drug Target and Biomarker for Various Diseases

Target Name: JPH4

NCBI ID: G84502

JPH4

JPH4: A Non-Coding RNA Molecule as A Potential Drug Target and Biomarker for Various Diseases

JPH4 (JPHL1), a small molecule protein, has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative disorders, and psychiatric disorders. JPH4 is a non-coding RNA molecule that has been shown to play a critical role in various cellular processes, including cell signaling, DNA replication, and repair. In this article, we will explore the biology of JPH4, its potential drug target status, and its potential as a biomarker for various diseases.

Biology of JPH4

JPH4 is a non-coding RNA molecule that was identified by bioinformatic analysis of RNA sequencing data. JPH4 is expressed in various tissues and cells of the human body, including the brain, heart, liver, and pancreas. It is primarily localized to the cytoplasm of cells and is not detected in the cell nucleus. JPH4 is composed of 215 amino acid residues and has a calculated molecular mass of 33.9 kDa.

JPH4 functions as a negative regulator of the microRNA (miRNA) pathway. The miRNA pathway is a post-transcriptional regulatory network that generates small non-coding RNAs, called microRNAs, from mRNAs. MicroRNAs play a critical role in various cellular processes, including cell signaling, gene expression, and tissue development.

JPH4 functions as a negative regulator of the miRNA pathway by binding to the miRNA binding site on target miRNAs. This interaction between JPH4 and miRNAs allows for the regulation of cellular processes and the expression of specific genes. JPH4 has been shown to interact with various miRNAs , including Let-7, which is a well-known miRNA that has been shown to play a role in various cellular processes, including cell signaling and cancer progression.

Potential Drug Target

JPH4 has been identified as a potential drug target due to its involvement in various cellular processes that are associated with the development and progression of various diseases. JPH4 has been shown to be involved in cell signaling, cell division, DNA replication, and repair, which are all critical processes that are affected in various diseases, including cancer, neurodegenerative disorders, and psychiatric disorders.

In cancer, JPH4 has been shown to be involved in the regulation of cell proliferation and the execution of various cellular processes that are critical for cancer growth and progression. For example, JPH4 has been shown to play a role in the regulation of the cell cycle , where it promotes the G1 phase and inhibits the S phase, which are both critical for cell growth and division.

In neurodegenerative disorders, JPH4 has been shown to be involved in the regulation of cellular processes that are critical for the development and progression of neurodegenerative disorders. For example, JPH4 has been shown to play a role in the regulation of neurotransmitter synthesis and release, which are critical for the function of neurons, and it has also been shown to be involved in the regulation of inflammation, which is a hallmark feature of neurodegenerative disorders.

In psychiatric disorders, JPH4 has been shown to be involved in the regulation of cellular processes that are critical for the development and progression of psychiatric disorders. For example, JPH4 has been shown to play a role in the regulation of neurotransmitter synthesis and release, which are critical for the function of neurons, and it has also been shown to be involved in the regulation of protein synthesis, which is critical for the development and maintenance of neural networks.

Biomarker Potential

JPH4 has also been shown to have potential as a biomarker for various diseases. For example, JPH4 has been shown to be involved in the regulation of cellular processes that are critical for the development and progression of cancer, and it has been shown to have a positive correlation with the development of various types of cancer, including breast, ovarian, and colorectal cancers.

JPH4 has also been shown to be involved in

Protein Name: Junctophilin 4

Functions: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity)

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