JPH3: A Protein Target of Great Interest (G57338)

Target Name: JPH3

NCBI ID: G57338

JPH3

JPH3: A Protein Target of Great Interest

JPH3 (TNRC22) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the superfamily of N-cysteine 鈥嬧?媍ontaining proteins (NCCPs), which are known for their role in various cellular processes. One of the unique features of JPH3 is its ability to modulate the activity of several neurotransmitter receptors, including dopamine, serotonin, and endothelial nitric oxide receptor (ENORM). This protein has been shown to play a crucial role in the regulation of pain, anxiety, and inflammation.

JPH3 is a drug target of great interest due to its potential to intervene in a wide range of physiological processes. Its ability to modulate the activity of neurotransmitter receptors makes it an attractive target for the development of new treatments for various psychiatric and neurological disorders.

Expression and Localization

JPH3 is highly expressed in a variety of tissues, including the brain, heart, and kidneys. It is expressed in the brain at levels of 1.2-1.5 mg/g of protein per liter of brain tissue and has been shown to localize to the basal ganglia, a region of the brain responsible for the coordination of movement and emotion.

JPH3 is also expressed in the heart, where it has been shown to localize to the left ventricle. It is thought to play a role in the regulation of contractility and cardiac output.

In addition, JPH3 is expressed in the kidneys, where it is involved in the regulation of urine output and blood pressure.

Function and Interaction

JPH3 is a protein that is involved in the regulation of multiple cellular processes. One of its most well-studied functions is its role in modulating the activity of neurotransmitter receptors. JPH3 has been shown to play a critical role in the regulation of dopamine and serotonin receptors, both of which play important roles in the transmission of pain, anxiety, and other neurological signals.

JPH3 has been shown to enhance the activity of dopamine receptors, which are involved in the transmission of reward and pleasure signals. This increase in dopamine activity is thought to contribute to the addictive properties of drugs that activate these receptors.

In addition to its role in modulating the activity of dopamine receptors, JPH3 has also been shown to play a critical role in the regulation of serotonin receptors. Serotonin is a neurotransmitter that is involved in the regulation of mood, appetite, and sleep, among other things. JPH3 has been shown to decrease the activity of serotonin receptors, which can lead to the effects of antidepressants, such as changes in mood and appetite.

JPH3 has also been shown to play a critical role in the regulation of ENORM, a receptor that is involved in the regulation of nitric oxide, a molecule that relaxes blood vessels and improves blood flow. This increase in nitric oxide activity is thought to contribute to the anti-inflammatory effects of certain drugs.

Drug Interference

JPH3 is a drug target that has been the focus of much research in recent years. One of the challenges in studying JPH3 is its ability to interact with multiple other proteins, making it difficult to predict its effects. However, studies have shown that JPH3 can interact with several other proteins, including the transcription factor, CREB, and the protein, p120JC.

In addition, JPH3 has been shown to interact with the protein, TrkB, which is involved in the regulation of cell survival and proliferation. This interaction may

Protein Name: Junctophilin 3

Functions: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory

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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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