JKAMP: A Protein Involved in Cell Signaling and Disease (G51528)

Target Name: JKAMP

NCBI ID: G51528

JKAMP

JKAMP: A Protein Involved in Cell Signaling and Disease

JKAMP (JNK-associated membrane protein) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the JNK signaling pathway, which is a well-known pathway that regulates various cellular processes in the body, including inflammation, stress responses, and cell survival.

The JNK signaling pathway is activated in response to stress, trauma, or other stimuli that cause inflammation or stress in the body. This pathway involves the activation of several transcription factors, including nuclear factor kappa B (NF-kappa-B), which leads to the production of various cytokines and chemokines that recruit immune cells to the site of injury or inflammation.

One of the proteins that is associated with the JNK signaling pathway is JKAMP. JKAMP is a 12-kDa protein that is composed of 110 amino acid residues. It has a characteristic J-shaped appearance due to the presence of a helical region in the middle of the protein that is reminiscent of a J.

JKAMP is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is highly expressed in the brain, where it is found in the postsynaptic density of dendrites in neurons, as well as in the cerebellum, where it is involved in the development and maintenance of motor skills.

JKAMP is also expressed in the heart, where it is involved in the regulation of contractility and heart rate. It is found in the cardiac muscle fibers, where it is thought to contribute to the regulation of cardiac contractility and heart rate.

In addition to its expression in the heart, JKAMP is also expressed in the kidneys. It is found in the podocytes of the kidney, where it is involved in the regulation of water and electrolyte balance.

JKAMP is a protein that is thought to be involved in several different signaling pathways. For example, it is involved in the regulation of pain perception, as well as in the regulation of inflammation and immune responses.

In addition to its involvement in signaling pathways, JKAMP is also a potential drug target. Several studies have suggested that JKAMP may be a useful target for the treatment of various diseases, including pain, inflammation, and fibrosis.

One potential mechanism by which JKAMP may be involved in the treatment of pain is by modulating the activity of pain-sensitive neurons. JKAMP has been shown to interact with a protein called TrkA, which is involved in the regulation of pain sensitivity. By modulating the activity of TrkA, JKAMP may be able to reduce the sensitivity of pain-sensitive neurons to pain.

Another potential mechanism by which JKAMP may be involved in the treatment of pain is by modulating the activity of immune cells. JKAMP has been shown to interact with a protein called PD-L1, which is involved in the regulation of immune cell function. By modulating the activity of PD-L1, JKAMP may be able to enhance the activity of immune cells, which may help to promote the fight against pain.

In addition to its potential role in pain regulation, JKAMP is also thought to be involved in the regulation of inflammation and immune responses. JKAMP has been shown to interact with several proteins that are involved in inflammation and immune responses, including TNF-伪, IL-6, and IFN-纬. By modulating the activity of these proteins, JKAMP may be able to regulate the immune response and contribute to the regulation of inflammation.

JKAMP may also be a potential biomarker for some diseases. For example, JKAMP has been shown to be elevated in the blood of individuals with rheumatoid arthritis (RA), a common autoimmune disorder. Additionally, JKAMP has

Protein Name: JNK1/MAPK8 Associated Membrane Protein

Functions: May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (By similarity)

The "JKAMP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about JKAMP comprehensively, including but not limited to:
•   general information;
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•   protein biological mechanisms;
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•   expression level;
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•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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