Understanding ITPR1-4: Potential Drug Target Or Biomarker (G3708)

Target Name: ITPR1

NCBI ID: G3708

ITPR1

Understanding ITPR1-4: Potential Drug Target Or Biomarker

ITPR1 (ITPR1 variant 3) is a protein that is expressed in the brain and is involved in the regulation of intracellular signaling pathways. The ITPR1 gene has been implicated in the development and progression of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders. Despite the significance of ITPR1 in the understanding of these disorders, much is still not known about this protein and its potential as a drug target or biomarker.

The ITPR1 gene has four splice variants, ITPR1-1, ITPR1-2, ITPR1-3, and ITPR1-4. ITPR1-1, ITPR1-2, and ITPR1-3 have been shown to have similar effects on intracellular signaling pathways, but ITPR1-4 has unique properties that make it a potential drug target or biomarker.

ITPR1-4 is a 21-kDa protein that is expressed in the brain and is involved in the regulation of several intracellular signaling pathways, including tyrosine signaling, G-protein-coupled receptor (GPCR) signaling, and estrogen signaling. ITPR1-4 has been shown to play a role in the development and progression of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.

One of the unique features of ITPR1-4 is its ability to interact with several different intracellular signaling pathways, making it a potential drug target or biomarker. For example, ITPR1-4 has been shown to interact with the tyrosine signaling pathway, which is involved in the regulation of cell growth, differentiation, and survival. Additionally, ITPR1-4 has been shown to interact with the GPCR signaling pathway, which is involved in the regulation of sensory perception and behavior.

In addition to its involvement in intracellular signaling pathways, ITPR1-4 has also been shown to play a role in the regulation of cellular processes that are important for brain function, such as synaptic plasticity and neuroprotection. ITPR1-4 has been shown to regulate the expression of genes that are involved in synaptic plasticity, which is the ability of the brain to change and adapt in response to experience. Additionally, ITPR1-4 has been shown to regulate the expression of genes that are involved in neuroprotection, which is the ability of the brain to protect itself from harmful substances and conditions.

Despite the significance of ITPR1-4 in the understanding of neurological disorders, much is still not known about this protein and its potential as a drug target or biomarker. Future research, including studies of the structure and function of ITPR1-4, will be necessary to fully understand its potential as a drug target or biomarker.

Conclusion

In conclusion, ITPR1 (ITPR1 variant 3) is a protein that is expressed in the brain and is involved in the regulation of intracellular signaling pathways. The ITPR1 gene has four splice variants, ITPR1-1, ITPR1-2, ITPR1-3, and ITPR1-4. ITPR1-1, ITPR1-2, and ITPR1-3 have been shown to have similar effects on intracellular signaling pathways, but ITPR1-4 has unique properties that make it a potential drug target or biomarker. Further research is needed to fully understand ITPR1-4's role in the development and progression of neurological disorders.

Protein Name: Inositol 1,4,5-trisphosphate Receptor Type 1

Functions: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity)

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