JAM2: A Protein Implicated in Cell-Cell Adhesion and Disease (G58494)

Target Name: JAM2

NCBI ID: G58494

JAM2

JAM2: A Protein Implicated in Cell-Cell Adhesion and Disease

JAM2, also known as junctional adhesion molecule B, is a protein that plays a crucial role in cell-cell adhesion. It is a member of the cadherin family, which is known for its role in cell-cell adhesion, and is expressed in a wide range of tissues and organs throughout the body.

JAM2 is involved in many different processes in the body, including cell signaling, migration, and the development and maintenance of tissues. It is expressed in various tissues, including the skin, hair, nails, lens, retina, liver, and pancreas, and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key functions of JAM2 is its role in cell-cell adhesion. This is the process by which cells stick together to form tissues and organs. JAM2 helps to regulate cell-cell adhesion by participating in the formation of tight junctions, which are the weakest type of cell-cell adhesion.

In addition to its role in cell-cell adhesion, JAM2 is also involved in many other cellular processes. For example, it has been shown to play a role in cell signaling, both in the intracellular signaling pathway and in the extracellular signaling pathway. JAM2 has also been shown to be involved in the regulation of cell migration, and has been implicated in the development and maintenance of tissues such as the brain and the heart.

JAM2 has also been shown to play a role in the development and progression of a number of diseases, including cancer. For example, studies have shown that JAM2 is often overexpressed in various types of cancer, and that inhibition of JAM2 has been shown to have therapeutic benefits in these diseases.

In addition to its potential therapeutic applications, JAM2 is also an attractive biomarker for a number of diseases. For example, JAM2 has been shown to be involved in the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Additionally, JAM2 has been shown to be involved in the development of certain autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis.

Overall, JAM2 is a protein that plays a crucial role in a wide range of cellular processes in the body. Its role in cell-cell adhesion, as well as its involvement in the development and progression of diseases, make it an attractive target for further research and potential therapeutic applications.

Protein Name: Junctional Adhesion Molecule 2

Functions: Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes (PubMed:11590146, PubMed:11823489, PubMed:24357068). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow (PubMed:24357068). At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium (PubMed:12239159). Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1 (PubMed:12070135). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity). May also play a role in angiogenesis (By similarity)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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