11beta-Hydroxysteroid Dehydrogenase (nonspecified subtype) Related Diseases

11beta-Hydroxysteroid Dehydrogenase (nonspecified subtype)

Related Diseases

1) Arthritis
Arthritis, also known as inflammatory joint disease, is related to rheumatoid arthritis and juvenile rheumatoid arthritis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Arthritis is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Entecavir and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and bone marrow, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and homeostasis/metabolism

2) Metabolic Diseases
3-Hydroxyacyl-Coa Dehydrogenase Deficiency, also known as hadh deficiency, is related to long-chain 3-hydroxyacyl-coa dehydrogenase deficiency and hyperinsulinemic hypoglycemia, familial, 4, and has symptoms including emaciation An important gene associated with 3-Hydroxyacyl-Coa Dehydrogenase Deficiency is HADH (Hydroxyacyl-CoA Dehydrogenase). The drugs Naloxone and Buprenorphine have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and skeletal muscle, and related phenotypes are feeding difficulties in infancy and growth delay

3) Diabetes Type 2
Type 2 Diabetes Mellitus, also known as insulin resistance, is related to diabetes mellitus and maturity-onset diabetes of the young, type 8, with exocrine dysfunction, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Type 2 Diabetes Mellitus is IRS1 (Insulin Receptor Substrate 1), and among its related pathways/superpathways are Nervous system development and Angiopoietin-like protein 8 regulatory pathway. The drugs Glipizide and Glycopyrronium have been mentioned in the context of this disorder. Affiliated tissues include Pancreas and Adipose, and related phenotypes are type ii diabetes mellitus and insulin resistance

4) Coronary Artery Disease
Coronary Heart Disease 1, also known as coronary heart disease, is related to angina pectoris and abdominal obesity-metabolic syndrome 1, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Coronary Heart Disease 1 is CX3CR1 (C-X3-C Motif Chemokine Receptor 1), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Simvastatin and Lovastatin have been mentioned in the context of this disorder. Affiliated tissues include Limb and Bone, and related phenotypes are Increased free cholesterol and Increased LDL uptake

5) Multiple Myeloma
Myeloma, Multiple, also known as multiple myeloma, is related to monoclonal gammopathy of uncertain significance and plasma cell neoplasm. An important gene associated with Myeloma, Multiple is LIG4 (DNA Ligase 4), and among its related pathways/superpathways are Breast cancer pathway and MAPK Signaling: Mitogens. The drugs Busulfan and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include Blood, and related phenotypes are osteopenia and pathologic fracture

6) Glioblastoma Multiforme
Glioblastoma, also known as glioblastoma multiforme, is related to brain cancer and glioma, and has symptoms including headache and seizures. An important gene associated with Glioblastoma is MIR21 (MicroRNA 21), and among its related pathways/superpathways is miRNAs involved in DNA damage response. The drugs Trametinib and Dabrafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and eye, and related phenotypes are glioblastoma multiforme and abnormal cell morphology

7) Chronic Lymphocytic Leukemia
Leukemia, Chronic Lymphocytic 2, also known as leukemia, chronic lymphocytic, susceptibility to, 2, is related to chronic lymphocytic leukemia/small lymphocytic lymphoma and chromosomal triplication, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Leukemia, Chronic Lymphocytic 2 is CLLS2 (Disrupted In B-Cell Neoplasia), and among its related pathways/superpathways are Hematopoietic Stem Cells and Lineage-specific Markers and Interleukin-4 and Interleukin-13 signaling. The drugs Valganciclovir and Chlorambucil have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and b cells, and related phenotypes are chronic lymphatic leukemia and immune system

8) Lymphoma, Follicular
Follicular Lymphoma, also known as lymphoma, follicular, is related to lymphoma and burkitt lymphoma. An important gene associated with Follicular Lymphoma is BCL10 (BCL10 Immune Signaling Adaptor), and among its related pathways/superpathways are Interleukin-4 and Interleukin-13 signaling and DNA damage response (only ATM dependent). The drugs Protective Agents and Neuroprotective Agents have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone marrow, and related phenotypes are fever and lymphoma

9) Turner's Syndrome
Turner Syndrome, also known as monosomy x, is related to 45,x/46,xy mixed gonadal dysgenesis and noonan syndrome 1. An important gene associated with Turner Syndrome is SHOX (Short Stature Homeobox), and among its related pathways/superpathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Endochondral ossification. The drugs Propofol and Cilostazol have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and kidney, and related phenotypes are short neck and osteopenia

10) Cancer, Prostate
Prostate Cancer, also known as prostate carcinoma, is related to breast cancer and prostate disease, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Prostate Cancer is CHEK2 (Checkpoint Kinase 2), and among its related pathways/superpathways are Endometrial cancer and Breast cancer pathway. The drugs Sodium citrate and Sildenafil have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and lymph node, and related phenotypes are prostate cancer and neoplasm

11) Cancer, Bladder
Bladder Cancer, also known as urinary bladder cancer, is related to bladder urothelial carcinoma and costello syndrome. An important gene associated with Bladder Cancer is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways/superpathways are Breast cancer pathway and MAPK Signaling: Mitogens. The drugs Tamsulosin and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include urinary bladder, lymph node and prostate, and related phenotypes are transitional cell carcinoma of the bladder and bladder neoplasm

12) Diabetes
Diabetes Mellitus, also known as diabetes, is related to type 2 diabetes mellitus and gestational diabetes, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Diabetes Mellitus is KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11), and among its related pathways/superpathways are Regulation of beta-cell development and Cell differentiation - expanded index. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone marrow and kidney.

13) Obesity
Body Mass Index Quantitative Trait Locus 11, also known as obesity, is related to leptin deficiency or dysfunction and type 2 diabetes mellitus, and has symptoms including high weight, symptoms and obesity, metabolically benign. An important gene associated with Body Mass Index Quantitative Trait Locus 11 is UCP3 (Uncoupling Protein 3), and among its related pathways/superpathways are Beta-2 adrenergic-dependent CFTR expression and Glucose / Energy Metabolism. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, liver and heart, and related phenotypes are obesity and decreased resting energy expenditure

14) Renal Failure
Kidney Disease, also known as renal failure, is related to chronic kidney disease and polycystic kidney disease, and has symptoms including polyuria An important gene associated with Kidney Disease is TSC1 (TSC Complex Subunit 1), and among its related pathways/superpathways are Ciliopathies and Bardet-Biedl syndrome. The drugs Amiodarone and Nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and bone marrow, and related phenotypes are homeostasis/metabolism and renal/urinary system

15) Overactive Bladder
Low Compliance Bladder, also known as overactive bladder, is related to interstitial cystitis and paine syndrome, and has symptoms including dysuria, urgency of micturition and prostatism. An important gene associated with Low Compliance Bladder is P2RX3 (Purinergic Receptor P2X 3), and among its related pathways/superpathways are Signal Transduction and Myometrial relaxation and contraction pathways. The drugs Propiverine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, smooth muscle and prostate.

16) Autoimmune Disease
Autoimmune Disease, also known as autoimmune diseases, is related to vitiligo-associated multiple autoimmune disease susceptibility 1 and systemic lupus erythematosus. An important gene associated with Autoimmune Disease is AIS4 (Autoimmune Disease, Susceptibility To, 4), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Sofosbuvir and Ledipasvir have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and skin, and related phenotypes are autoimmune antibody positivity and endocrine/exocrine gland

17) Dyslipidemia
Lipid Metabolism Disorder, also known as dyslipidemia, is related to hyperlipoproteinemia, type iii and hypobetalipoproteinemia, familial, 1. An important gene associated with Lipid Metabolism Disorder is LIPC (Lipase C, Hepatic Type), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Tocopherol and Aripiprazole have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and bone marrow, and related phenotypes are no effect and no effect

18) Psoriasis
Psoriasis is related to psoriasis 7 and psoriasis 10, and has symptoms including exanthema, pruritus and psoriasiform rash. An important gene associated with Psoriasis is MIR203A (MicroRNA 203a), and among its related pathways/superpathways are miRNAs involvement in the immune response in sepsis and Cell differentiation - expanded index. The drugs Metformin and Vedolizumab have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and endothelial.

19) Glaucoma
Intraocular Pressure Quantitative Trait Locus, also known as glaucoma, is related to primary angle-closure glaucoma and open-angle glaucoma. An important gene associated with Intraocular Pressure Quantitative Trait Locus is ZEB1 (Zinc Finger E-Box Binding Homeobox 1), and among its related pathways/superpathways are Clear cell renal cell carcinoma pathways and BMP signaling in eyelid development. The drugs Topiramate and Bromfenac have been mentioned in the context of this disorder. Affiliated tissues include Eye, retina and bone marrow, and related phenotypes are homeostasis/metabolism and nervous system

20) Non-Hodgkin Lymphoma
Lymphoma, also known as non-hodgkin malignant lymphoma nos, is related to lymphoma, hodgkin, classic and lymphoma, non-hodgkin, familial. An important gene associated with Lymphoma is PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), and among its related pathways/superpathways are IL-9 Signaling Pathways and NF-kappaB Signaling. The drugs Ferrous succinate and Posaconazole have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and myeloid, and related phenotypes are immune system and hematopoietic system

The "11beta-Hydroxysteroid Dehydrogenase (nonspecified subtype) Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about 11beta-Hydroxysteroid Dehydrogenase (nonspecified subtype) comprehensively including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

Disease Target / Biomarker

<< Back