SLC17A8: Unlocking The Gene's Many Functions (G246213)

Target Name: SLC17A8

NCBI ID: G246213

SLC17A8

SLC17A8: Unlocking The Gene's Many Functions

SLC17A8 is a gene that encodes a protein known as solute carrier family 17 member 8. The protein is a member of the SLC family, which is a family of transmembrane proteins that play a vital role in the transfer of solutes and ions across cell membranes. SLC17A8 is unique because it has a unique variant form, known as SLC17A8 variant 1.

SLC17A8 is a protein that is expressed in many different tissues and cells throughout the body. It is most highly expressed in the brain, where it is involved in the transport of essential nutrients such as glucose and amino acids into the cell. It is also expressed in other tissues, including the heart, kidneys, and liver.

One of the unique features of SLC17A8 is its role in the regulation of blood pressure. It has been shown to play a key role in the regulation of sodium and water intake, which is important for maintaining proper blood pressure. SLC17A8 has been shown to interact with several other genes that are involved in blood pressure regulation, including the sodium chloride transporter (SLC12A1) and the water regulatory gene (WT1).

Another function of SLC17A8 is its role in cell signaling. It has been shown to play a role in several signaling pathways, including the TGF-β pathway and the NF-kappa-B pathway. These pathways are involved in the regulation of cell growth, differentiation, and inflammation.

SLC17A8 has also been shown to be involved in the development and progression of several diseases, including cancer. For example, it has been shown to be involved in the development of neuroblastoma, a type of cancer that arises from the neural stem cells that give rise to all of the different types of cells in the body. It has also been shown to be involved in the development of pancreatic cancer, a type of cancer that arises from the pancreatic beta cells, which produce hormones that regulate blood sugar levels.

Despite its many functions, SLC17A8 is still not well understood. There are only a few studies that have been published on its role in different tissues and conditions. However, these studies have shown that SLC17A8 is involved in a wide range of physiological processes that are important for human health.

In conclusion, SLC17A8 is a protein that is involved in a wide range of physiological processes that are important for human health. Its unique variant form, SLC17A8 variant 1, and its involvement in the regulation of blood pressure, cell signaling, and disease development make it an attractive target for further research. Further studies are needed to fully understand the role of SLC17A8 in different tissues and conditions, and to develop new treatments for diseases that are caused by its dysfunction.

Protein Name: Solute Carrier Family 17 Member 8

Functions: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, sodium and phosphate (PubMed:33440152, PubMed:12151341). At the synaptic vesicle membrane, mainly functions as an uniporter that mediates the uptake of L-glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:12151341). The L-glutamate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed:12151341). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (Probable). The symporter activity is electrogenic (PubMed:33440152). Moreover, operates synergistically with SLC18A3/VACHT under a constant H(+) gradient, thereby allowing striatal vesicular acetylcholine uptake (By similarity)

The "SLC17A8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC17A8 comprehensively, including but not limited to:
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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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