OR13: A GPCR Involved in Smell and Olfactory System Regulation
OR13: A GPCR Involved in Smell and Olfactory System Regulation
Olfactory receptor family 13 (OR13) is a subfamily of G protein-coupled receptors (GPCRs) that play a crucial role in mediating sensory processes, including smell and taste. OR13 is a GPCR that is expressed in the olfactory system, which is responsible for detecting and recognizing scents in the environment.
OR13 is a transmembrane protein that consists of an extracellular portion, a transmembrane region, and an intracellular portion. The extracellular portion of OR13 consists of a N-terminus that is involved in cell-signaling interactions and a C-terminus that is involved in the formation of a complex with other GPCRs, known as the GPCR signaling complex. The transmembrane region of OR13 contains a putative intracellular signaling pathway that involves the formation of a protein-protein interaction (PPI) with the intracellular domain of the related GPCR OR12. The intracellular portion of OR13 contains a unique N-terminus that is involved in the formation of a PPI with the protein neurotransmitter GABA.
OR13 is a GPCR that is known for its role in mediating the sense of smell. It is expressed in the olfactory system and is involved in the perception of a wide variety of scents, including odors such as those associated with food, flowers, and cleaning products. OR13 is also involved in the regulation of the growth and differentiation of olfactory epithelial cells, which are responsible for maintaining the structure and function of the olfactory system.
Due to its involvement in the sense of smell, OR13 is a potential drug target for the treatment of olfactory disorders such as Alzheimer's disease, Parkinson's disease, and chronic insomnia. Currently, there are no FDA-approved drugs that specifically target OR13. However, research is being conducted to develop small molecules and other compounds that can modulate the activity of OR13 and improve the function of the olfactory system.
In addition to its potential drug-targeting potential, OR13 is also a potential biomarker for the diagnosis and monitoring of olfactory disorders. The loss of OR13 has been observed in the brains of individuals with Alzheimer's disease, and blocking the activity of OR13 has been shown to improve cognitive function in animal models of the disease. Additionally, changes in the expression and function of OR13 have been observed in individuals with Parkinson's disease, suggesting that they may also be a potential biomarker for this disease.
Overall, OR13 is a GPCR that is involved in the sense of smell and the regulation of the olfactory system. Its unique structure and function make it a potential drug target and a potential biomarker for a variety of disorders. Further research is needed to fully understand the role of OR13 in the sense of smell and its potential as a drug and biomarker.
Protein Name: Olfactory Receptor Family 13 Subfamily J Member 1
Functions: Odorant receptor
The "OR13J1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OR13J1 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
OR13Z2P | OR14A16 | OR14A2 | OR14C36 | OR14I1 | OR14J1 | OR14L1P | OR1A1 | OR1A2 | OR1B1 | OR1C1 | OR1D2 | OR1D4 | OR1D5 | OR1E1 | OR1E2 | OR1E3 | OR1F1 | OR1F2P | OR1G1 | OR1I1 | OR1J1 | OR1J2 | OR1J4 | OR1K1 | OR1L1 | OR1L3 | OR1L4 | OR1L6 | OR1L8 | OR1M1 | OR1N1 | OR1N2 | OR1P1 | OR1Q1 | OR1S1 | OR1S2 | OR2A1 | OR2A1-AS1 | OR2A12 | OR2A14 | OR2A2 | OR2A20P | OR2A25 | OR2A4 | OR2A42 | OR2A7 | OR2A9P | OR2AE1 | OR2AG1 | OR2AG2 | OR2AJ1 | OR2AK2 | OR2AL1P | OR2AM1P | OR2AP1 | OR2AT4 | OR2B11 | OR2B2 | OR2B3 | OR2B6 | OR2C1 | OR2C3 | OR2D2 | OR2D3 | OR2F1 | OR2F2 | OR2G2 | OR2G3 | OR2G6 | OR2H1 | OR2H2 | OR2I1P | OR2J1 | OR2J2 | OR2J3 | OR2J4P | OR2K2 | OR2L13 | OR2L1P | OR2L2 | OR2L3 | OR2L5 | OR2L8 | OR2L9P | OR2M1P | OR2M2 | OR2M3 | OR2M4 | OR2M5 | OR2M7 | OR2Q1P | OR2S2 | OR2T1 | OR2T10 | OR2T11 | OR2T12 | OR2T2 | OR2T27 | OR2T29
