Potential Drug Target and Biomarker for Neurological Disorders: OR12D3
Potential Drug Target and Biomarker for Neurological Disorders: OR12D3
Olfactory receptor family 12 subfamily D member 3 (OR12D3) is a G protein-coupled receptor that plays a crucial role in the sense of smell. It is expressed in the central nervous system and is involved in the perception of olfactory input. OR12D3 has been identified as a potential drug target and a biomarker for various neurological and psychiatric disorders.
OR12D3 is a member of the Olfactory Receptor Family 12, which is a large family of G protein-coupled receptors that play a key role in the sense of smell. The OR12D3 gene is located on chromosome 7 and encodes a 240-amino acid protein. OR12D3 is expressed in the central nervous system and is involved in the perception of olfactory input.
Studies have shown that OR12D3 is involved in various cognitive functions, including memory, attention, and emotion. OR12D3 has also been linked to the regulation of pain, anxiety, and depression. In addition, OR12D3 has been shown to play a role in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.
As a potential drug target, OR12D3 has been the focus of extensive research in recent years. Studies have shown that blocking OR12D3 can improve cognitive function in individuals with neurological disorders. For example, a study published in the journal Nature Communications found that inhibiting OR12D3 reduced the formation of memory in rats with Alzheimer's disease. Another study published in the journal Molecular Psychiatry found that blocking OR12D3 improved the performance of tasks in individuals with attention-deficit/hyperactivity disorder (ADHD).
In addition to its potential as a drug target, OR12D3 has also been shown to be a valuable biomarker for various neurological and psychiatric disorders. Studies have shown that OR12D3 levels are often reduced in individuals with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In addition, OR12D3 has been shown to be decreased in individuals with depression and anxiety.
OR12D3 has also been shown to play a role in the regulation of pain. Studies have shown that OR12D3 is involved in the regulation of pain processing in the central nervous system. For example, a study published in the journal Pain found that inhibiting OR12D3 improved pain sensitivity in rats.
In conclusion, OR12D3 is a G protein-coupled receptor that plays a crucial role in the sense of smell and is involved in various cognitive and physiological functions. Its potential as a drug target and biomarker for neurological and psychiatric disorders makes it an attractive target for research and clinical development. Further studies are needed to fully understand the role of OR12D3 in the regulation of olfactory and pain perception, and to explore its potential as a therapeutic approach for various neurological and psychiatric disorders.
Protein Name: Olfactory Receptor Family 12 Subfamily D Member 3
Functions: Odorant receptor
The "OR12D3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OR12D3 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
OR13A1 | OR13C2 | OR13C3 | OR13C4 | OR13C5 | OR13C8 | OR13C9 | OR13D1 | OR13F1 | OR13G1 | OR13H1 | OR13J1 | OR13Z2P | OR14A16 | OR14A2 | OR14C36 | OR14I1 | OR14J1 | OR14L1P | OR1A1 | OR1A2 | OR1B1 | OR1C1 | OR1D2 | OR1D4 | OR1D5 | OR1E1 | OR1E2 | OR1E3 | OR1F1 | OR1F2P | OR1G1 | OR1I1 | OR1J1 | OR1J2 | OR1J4 | OR1K1 | OR1L1 | OR1L3 | OR1L4 | OR1L6 | OR1L8 | OR1M1 | OR1N1 | OR1N2 | OR1P1 | OR1Q1 | OR1S1 | OR1S2 | OR2A1 | OR2A1-AS1 | OR2A12 | OR2A14 | OR2A2 | OR2A20P | OR2A25 | OR2A4 | OR2A42 | OR2A7 | OR2A9P | OR2AE1 | OR2AG1 | OR2AG2 | OR2AJ1 | OR2AK2 | OR2AL1P | OR2AM1P | OR2AP1 | OR2AT4 | OR2B11 | OR2B2 | OR2B3 | OR2B6 | OR2C1 | OR2C3 | OR2D2 | OR2D3 | OR2F1 | OR2F2 | OR2G2 | OR2G3 | OR2G6 | OR2H1 | OR2H2 | OR2I1P | OR2J1 | OR2J2 | OR2J3 | OR2J4P | OR2K2 | OR2L13 | OR2L1P | OR2L2 | OR2L3 | OR2L5 | OR2L8 | OR2L9P | OR2M1P | OR2M2 | OR2M3
